Anti-Mouse CD45.1 Antibody, Clone A20

Mouse monoclonal IgG2a antibody against mouse CD45.1

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Mouse monoclonal IgG2a antibody against mouse CD45.1
From: 70 USD

Overview

The A20 monoclonal antibody reacts with mouse alloantigen CD45.1 (Ly5.1) expressed by all hematopoietic cells except mature erythrocytes and platelets in mouse strains RIII, SJL/J, STS/A, and DA. Clone A20 does not react with leukocytes that express CD45.2 alloantigen. CD45.1 is an allelic form of CD45 (leukocyte common antigen), a 180 - 240 kDa type I transmembrane glycoprotein. CD45 is a member of the protein tyrosine phosphatase (PTP) family and functions in a number of immunoregulatory processes, including cell activation, growth, lymphocyte development, differentiation, and oncogenic transformation. The isoforms of CD45 correlate to specific cell types, as well as specific activation and maturation states of immune cells. The A20 monoclonal antibody has been used extensively in adoptive cell transfer and bone marrow transplantation studies in mice, allowing for the differentiation of CD45.2- and CD45.1- expressing cells.
Subtype:
Primary Antibodies
Target Antigen:
CD45.1
Reactive Species:
Mouse
Conjugation:
Unconjugated; Biotin
Host Species:
Mouse
Cell Type:
Myeloid Cells; Granulocytes and Subsets; Lymphocytes; Hematopoietic Stem and Progenitor Cells
Application:
Flow Cytometry; Immunofluorescence; Immunohistochemistry
Area of Interest:
Immunology

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Data and Publications

Data

Data for Biotin-Conjugated

Figure 1. Data for Biotin-Conjugated

Flow cytometry analysis of SLJ mouse splenocytes labeled with Anti-Mouse CD45.1 Antibody, Clone A20, Biotin followed by streptavidin (SAV) PE (filled histogram).

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.