Anti-Mouse CD152 (CTLA-4) Antibody, Clone UC10-4F10-11

Hamster (Armenian) monoclonal IgG antibody against mouse CD152 (CTLA-4)
From: 59 USD

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Hamster (Armenian) monoclonal IgG antibody against mouse CD152 (CTLA-4)
From: 59 USD

Overview

The UC10-4F10-11 antibody reacts with an extracellular epitope on mouse CD152 (CTLA-4), a type I transmembrane glycoprotein receptor expressed on the surface of activated T and B cells and thymocytes. CD152 comprises a disulfide-linked homodimer of ~35 kDa subunits and is a member of the immunoglobulin protein superfamily. It functions as an antagonistic homolog of CD28 by binding the CD28 co-stimulatory ligands, CD80 and CD86. CD152 thereby acts to inhibit CD28-mediated stimulation during the early stages of T cell expansion. It also contributes to the suppressor function of T regulatory cells. CD152 has important roles in immunological tolerance and immunity, and mutations in its cognate gene have been associated with certain autoimmune disorders.
Subtype:
Primary Antibodies
Target Antigen:
CD152 (CTLA-4)
Alternative Names:
CTLA-4, Cytotoxic T lymphocyte-associated antigen-4, Ly-56
Reactive Species:
Mouse
Conjugation:
APC; PE; Unconjugated
Host Species:
Hamster
Cell Type:
T Cells, Other Subsets
Application:
Flow Cytometry; Functional Assay; Immunoprecipitation
Clone:
UC10-4F10-11
Gene ID:
12477
Isotype:
IgG1, kappa

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

Figure showing flow cytometry analysis of Con A-stimulated (3 days) C57BL/6 mouse splenocytes labeled with Anti-Mouse CD152 (CTLA-4) Antibody, Clone UC10-4F10-11, APC or an Armenian hamster IgG, APC isotype control antibody.

Figure 1. Data for Anti-Mouse CD152 Antibody, Clone UC10-4F10-11, APC

Flow cytometry analysis of Con A-stimulated (3 days) C57BL/6 mouse splenocytes labeled with Anti-Mouse CD152 (CTLA-4) Antibody, Clone UC10-4F10-11, APC (filled histogram) or an Armenian hamster IgG, APC isotype control antibody (solid line histogram).

Figure showing flow cytometry analysis of Con-A stimulated (3 days) C57BL/6 mouse splenocytes labeled with Anti-Mouse CD152 (CTLA-4) Antibody, Clone UC10-4F10-11, PE or an Armenian hamster IgG, PE isotype control antibody.

Figure 2. Data for Anti-Mouse CD152 Antibody, Clone UC10-4F10-11, PE

Flow cytometry analysis of Con-A stimulated (3 days) C57BL/6 mouse splenocytes labeled with Anti-Mouse CD152 (CTLA-4) Antibody, Clone UC10-4F10-11, PE (filled histogram) or an Armenian hamster IgG, PE isotype control antibody (solid line histogram).

Figure showing flow cytometry analysis of Con A-stimulated (3 days) C57BL/6 mouse splenocytes labeled with Anti-Mouse CD152 (CTLA-4) Antibody, Clone UC10-4F10-11, followed by a goat anti-Armenian hamster IgG antibody, FITC or an Armenian hamster IgG isotype control antibody, followed by a goat anti-Armenian hamster IgG, FITC.

Figure 3. Data for Anti-Mouse CD152 Antibody, Clone UC10-4F10-11, FITC

Flow cytometry analysis of Con A-stimulated (3 days) C57BL/6 mouse splenocytes labeled with Anti-Mouse CD152 (CTLA-4) Antibody, Clone UC10-4F10-11, followed by a goat anti-Armenian hamster IgG antibody, FITC (filled histogram) or an Armenian hamster IgG isotype control antibody, followed by a goat anti-Armenian hamster IgG, FITC (solid line histogram).

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.