Anti-Human CD43 Antibody, Clone CD43-10G7
Mouse monoclonal IgG1 antibody against human CD43
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Anti-Human CD43 Antibody, Clone CD43-10G7 -
Anti-Human CD43 Antibody, Clone CD43-10G7, PE -
Label for Anti-Human CD43 Antibody, Clone CD43-10G7, APC -
Label for Anti-Human CD43 Antibody, Clone CD43-10G7, APC -
Label for Anti-Human CD43 Antibody, Clone CD43-10G7 -
Label for Anti-Human CD43 Antibody, Clone CD43-10G7, PE -
Label for Anti-Human CD43 Antibody, Clone CD43-10G7, PE
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Overview
The CD43-10G7 antibody reacts with human CD43, a type I transmembrane sialoglycoprotein expressed on the surface of most human hematopoietic cells, including thymocytes, peripheral T cells, NK cells, monocytes, granulocytes, some B cells (activated B cells and an early B cell subset in bone marrow), plasma cells, and hematopoietic progenitor cells. Low expression levels are observed on platelets. CD43 exhibits different glycoforms in the range of ~95 - 135 kDa, depending on the cell type. It binds ligands such as CD54 and CD169 (Siglec-1) and plays regulatory roles in cell adhesion and activation, apoptosis and tumor progression, and is used a marker for discriminating normal from neoplastic T cells and B cells within tissues. Binding of the CD43-10G7 antibody to CD43 on neutrophils reportedly induces homotypic cell adhesion.
Subtype:
Primary Antibodies
Target Antigen:
CD43
Alternative Names:
Leukocyte sialoglycoprotein, Leukosialin, Ly-48, Sialophorin, W3/13
Reactive Species:
Human
Conjugation:
APC; PE; Unconjugated
Host Species:
Mouse
Cell Type:
B Cells
Application:
Functional Assay; Flow Cytometry; Immunoprecipitation
Area of Interest:
Immunology
Clone:
CD43-10G7
Gene ID:
6693
Isotype:
IgG1, kappa
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Scientific Resources
Product Documentation
Document Type
Product Name
Catalog #
Lot #
Language
60085AZ, 60085AZ.1
All
60085PE, 60085PE.1
All
Educational Materials
(5)
Product Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages for
Workflow Stages
Data and Publications
Data
Figure 1. Data for APC-Conjugated
(A) Flow cytometry analysis of human buffy coat nucleated cells labeled with Anti-Human CD43 Antibody, Clone CD43-10G7, APC and Anti-Human CD45 Antibody, Clone HI30, PE (Catalog #60018PE).
(B) Flow cytometry analysis of human buffy coat nucleated cells processed with the EasySep™ HLA Whole Blood B Cell Positive Selection Kit and labeled with Anti-Human CD43 Antibody, Clone CD43-10G7, APC and Anti-Human CD45 Antibody, Clone HI30, PE. Note: CD43 is not expressed on resting B cells.
(C) Flow cytometry analysis of human buffy coat nucleated cells labeled with a mouse IgG1, kappa APC isotype control antibody and Anti-Human CD45 Antibody, Clone HI30, PE.
Figure 2. Data for PE-Conjugated
(A) Flow cytometry analysis of human buffy coat nucleated cells labeled with Anti-Human CD43 Antibody, Clone CD43-10G7, PE and Anti-Human CD45 Antibody, Clone HI30, APC (Catalog #60018AZ).
(B) Flow cytometry analysis of human buffy coat nucleated cells processed with the EasySep™ HLA Whole Blood B Cell Positive Selection Kit and labeled with Anti-Human CD43 Antibody, Clone CD43-10G7, PE and Anti-Human CD45 Antibody, Clone HI30, APC. Note: CD43 is not expressed on resting B cells.
(C) Flow cytometry analysis of human buffy coat nucleated cells labeled with a mouse IgG1, kappa PE isotype control antibody and Anti-Human CD45 Antibody, Clone HI30, APC.
Figure 3. Data for Unconjugated
Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD43 Antibody, Clone CD43-10G7, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (Catalog #60138FI) (filled histogram), or a mouse IgG1, kappa isotype control antibody, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (solid line histogram).
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.