Anti-Human CD41 Antibody, Clone HIP8

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD41
Catalog #
60114_C
Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD41
From: 101 USD

Overview

The HIP8 antibody reacts with the ~125 kDa GPIIbα subunit of human CD41, a heterodimeric integrin expressed primarily on platelets, megakaryocytes, monocytes, and acute megakaryoblastic leukemia cells. The GPIIbα subunit is linked to a smaller ~25 kDa subunit (GPIIbβ) by a single disulfide bond. Three isoforms of CD41 that are generated by alternative splicing have been identified, one of which is expressed only by cancerous cells. CD41 associates non-covalently with CD61 (integrin b3) in a calcium-dependent manner to form the CD41/CD61 (or GPIIb/IIIa) complex, which has been identified as a receptor for several ligands, including fibrinogen, fibronectin, vitronectin, and thrombin. Binding to the CD41/CD61 complex involves an RGD tripeptidyl sequence in the ligand, and both ligand occupancy and ligand-mediated receptor clustering are functionally important in the integrin-mediated response. The HIP8 antibody reportedly blocks platelet aggregation and inhibits the activation of platelets by several compounds.
Subtype
Primary Antibodies
Target Antigen
CD41
Alternative Names
GPIIb, Integrin alpha 2b, Integrin alpha llb, ITGA2B, Platelet glycoprotein IIb
Reactive Species
Baboon, Capuchin Monkey, Cynomolgus, Rhesus, Chimpanzee, Human, Pig
Conjugation
APC, FITC, PE, Unconjugated
Host Species
Mouse
Cell Type
Megakaryocytes, Platelets
Species
Human, Non-Human Primate, Other
Application
CyTOF, Flow Cytometry, Functional Assay, Immunofluorescence, Immunohistochemistry, Neutralization and Blocking
Area of Interest
Immunology
Clone
HIP8
Gene ID
3674
Isotype
IgG1, kappa

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Anti-Human CD41 Antibody, Clone HIP8
Catalog #
60114
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD41 Antibody, Clone HIP8, APC
Catalog #
60114AZ, 60114AZ.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD41 Antibody, Clone HIP8, FITC
Catalog #
60114FI, 60114FI.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD41 Antibody, Clone HIP8, PE
Catalog #
60114PE, 60114PE.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD41 Antibody, Clone HIP8
Catalog #
60114
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD41 Antibody, Clone HIP8, APC
Catalog #
60114AZ, 60114AZ.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD41 Antibody, Clone HIP8, FITC
Catalog #
60114FI, 60114FI.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD41 Antibody, Clone HIP8, PE
Catalog #
60114PE, 60114PE.1
Lot #
All
Language
English

Educational Materials (2)

Brochure
Reliable Antibodies for Your Research
Wallchart
Human Immune Cytokines

Data and Publications

Data

Data for unconjugated

Figure 1. Data for Unconjugated

Flow cytometry analysis of human platelets labeled with Anti-Human CD41 Antibody, Clone HIP8, followed by a rat anti-mouse IgG1 antibody, PE (filled histogram), or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21 (Catalog #60070), followed by a rat anti-mouse IgG1 antibody, PE (solid line histogram).

Data for APC-Conjugated

Figure 2. Data for APC-Conjugated

Flow cytometry analysis of human platelets labeled with Anti-Human CD41 Antibody, Clone HIP8, APC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, APC (Catalog #60070AZ, solid line histogram).

Data for FITC-Conjugated

Figure 3. Data for FITC-Conjugated

Flow cytometry analysis of human platelets labeled with Anti-Human CD41 Antibody, Clone HIP8, FITC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, FITC (Catalog #60070FI, solid line histogram).

Data for PE-Conjugated

Figure 4. Data for PE-Conjugated

Flow cytometry analysis of human platelets labeled with Anti-Human CD41 Antibody, Clone HIP8, PE (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, PE (Catalog #60070PE, solid line histogram).

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