Anti-Human CD105 Antibody, Clone SN6h, APC

Mouse monoclonal IgG1 antibody against human, mouse CD105 (endoglin)

More Views

Anti-Human CD105 Antibody, Clone SN6h, APC

Mouse monoclonal IgG1 antibody against human, mouse CD105 (endoglin)

25 Tests
Catalog #100-0243
279 USD

Overview

The SN6h antibody reacts with CD105 (Endoglin), an ~180 kDa cell-surface glycoprotein that is a disulfide-bonded homodimer comprising ~90 kDa type I transmembrane subunits. CD105 is a component of the TGF-β receptor complex and is expressed by vascular endothelial smooth muscle cells, syncytiotrophoblasts of placenta, and activated macrophages, and at relatively low levels by stromal fibroblasts. Its expression is also observed in some types of tumors, and levels are up-regulated on the endothelium during angiogenesis. In concert with signaling receptors, CD105 binds to TGF-β1 and TGF-β3 with high affinity, but does not bind TGF-β2. Other ligands reportedly include Activin A, BMP-2, BMP-7, and BMP-9. CD105 has important roles in angiogenesis, cardiovascular development, and vascular remodeling, and the protein serves a regulatory role in cytoskeletal reorganization by modulating the sites of focal adhesion and cellular migration. Certain mutations in CD105 result in the autosomal dominant disorder hereditary hemorrhagic telangiectasia (HHT). The epitope of the SN6h antibody is reportedly localized within the Ala119-Gly230 sequence of the N-terminal OR1 (orphan region 1) domain. CD105 is often used in combination with CD73 and CD90 to phenotype mesenchymal stromal cells.
Contains:
Phosphate-buffered solution, pH 7.2, containing 0.09%
sodium azide and 0.2% (w/v) bovine serum albumin
Subtype:
Primary Antibodies
Target Antigen:
CD105 (Endoglin)
Alternative Names:
Cell surface MJ7/18 antigen, Edg, END, ENG, HHT1, ORW1
Reactive Species:
Human
Conjugation:
APC
Host Species:
Mouse
Cell Type:
Mesenchymal Stromal Cells
Application:
Flow Cytometry
Area of Interest:
Endothelial Cell Biology; Stem Cell Biology
Clone:
SN6h
Gene ID:
2022
Isotype:
IgG1, kappa

Scientific Resources

Educational Materials

(1)

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

Flow cytometry analysis of different types of human mesenchymal stromal cells (MSCs).

Figure 1. Flow cytometry analysis of different types of human mesenchymal stromal cells (MSCs)

Flow cytometry analysis of (A) human bone marrow-derived mesenchymal stromal cells (BM-MSCs), (B) human umbilical cord-derived mesenchymal stromal cells (UC-MSCs), (C) human adipose tissue-derived MSCs (ADSCs), (D) human induced pluripotent stem cell-derived mesenchymal progenitor cells (iPSC-MPCs), and (E) human dental pulp-derived mesenchymal stromal cells (DPSCs). The cells were cultured in MesenCult™-ACF Plus Medium (Catalog #05445) then labeled with Anti-Human CD105 (Endoglin) Antibody, Clone SN6h, APC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, APC (Catalog #60070AZ; solid line histogram).

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.