Anti-Beta-Tubulin III Antibody, Clone TUJ1

Mouse monoclonal IgG2a antibody against human, mouse, rat beta­tubulin III
Anti-Beta-Tubulin III Antibody, Clone TUJ1

Mouse monoclonal IgG2a antibody against human, mouse, rat beta-tubulin III, unconjugated

250 µL
Catalog # 60052
729 USD

Overview

The TUJ1 antibody reacts with beta-tubulin III, an ~50 - 55 kDa structural protein that is a component of tubulin. Tubulin is the major component of microtubules within the cytoskeleton and is assembled from heterodimers of alpha and beta tubulin subunits. The beta III isoform of tubulin, also known as neuron-specific class III beta-tubulin, is expressed primarily in neurons and is widely used as a marker to distinguish neurons from other cell types. Beta-tubulin III contributes to microtubule formation in neuronal cell bodies and axons, a function involving GTP binding, and plays roles in axonal transport, neuronal cell proliferation, and differentiation. It is highly expressed in several types of cancer and is a predictive and prognostic marker for various tumors, for example, being found in neoplastic but not in normal glial cells. The TUJ1 antibody is expected to recognize all mammalian homologs of beta-tubulin III and the epitope has reportedly been mapped to the C-terminal 15 amino acids of the protein.
Subtype
Primary Antibodies
Target Antigen
Beta-Tubulin III
Alternative Names
CDCBM, CDCBM1, CFEOM3, CFEOM3A, Class III beta-tubulin, FEOM3, TUBB4, Tubulin beta-3 chain, Tubulin beta-III, Tubulin beta-4 chain
Reactive Species
Human, Mouse, Other, Rat
Conjugation
Unconjugated
Host Species
Mouse
Cell Type
Neural Cells, PSC-Derived, Neurons
Species
Human, Mouse, Rat
Application
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Area of Interest
Neuroscience, Stem Cell Biology
Clone
TUJ1
Gene ID
10381
Isotype
IgG2a, kappa

Related Products

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Anti-Beta-Tubulin III Antibody, Clone TUJ1
Catalog #
60052
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Beta-Tubulin III Antibody, Clone TUJ1
Catalog #
60052
Lot #
All
Language
English

Educational Materials(5)

Brochure
Primary Neuronal Culture: Standardized Media and Reagents
Brochure
BrainPhys™ Neuronal Medium for Improved Neuronal Function
Brochure
hPSC-Derived Neural Cell Research
Brochure
Reliable Antibodies for Your Research
Technical Bulletin
Cryogenic Tissue Processing and Section Immunofluorescence of Cerebral Organoids

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

E18 cortical rat neurons were cultured using NeuroCult™ SM1 Neuronal Culture Kit on poly-L-ornithine and laminin-coated glass coverslips, then fixed and labeled with Anti-Beta-Tubulin III Antibody, Clone TUJ1, followed by donkey anti-mouse IgG, Alexa Fluor® 488, and counterstained with DAPI.

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