Mouse Recombinant RANTES (CCL5)

Regulated upon activation, normal T cell expressed and secreted

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Regulated upon activation, normal T cell expressed and secreted
From: 202 USD

Overview

RANTES (regulated upon activation, normal T cell expressed and secreted), also known as CCL5, is a member of the CC family of chemokines and is able to recruit leukocytes to sites of inflammation (Schall et al.). RANTES is secreted by T lymphocytes, macrophages, platelets, synovial fibroblasts, tubular epithelium, and certain types of tumor cells (Aldinucci & Colombatti; Soria & Ben-Baruch). This chemokine exerts its effect by interacting with the chemokine receptors CCR1, CCR3, CCR4, and CCR5. RANTES plays an active role in recruiting a variety of leukocytes into inflammatory sites, including T cells, macrophages, eosinophils, and basophils. In collaboration with certain cytokines that are released by T cells such as IL-2 and IFN-γ, RANTES also induces the activation and proliferation of NK cells to generate CC chemokine-activated killer cells, which are highly cytolytic (Lv et al.; Maghazachi et al.). It has been shown that RANTES produced by CD8+ T cells inhibits HIV infection of primary human peripheral blood mononuclear cells (Appay & Rowland-Jones; Cocchi et al.).
Alternative Names:
D17S136, Eosinophil chemotactic cytokine, Regulated upon activation normally T-expressed and secreted, SIS-delta, Small-inducible cytokine A5, T-cell specific protein p288
Cell Type:
B Cells; Dendritic Cells; Mesenchymal Stem and Progenitor Cells; Monocytes; NK Cells; T Cells; T Cells, CD4+; T Cells, CD8+
Species:
Mouse
Area of Interest:
Immunology; Stem Cell Biology
Molecular Weight:
7.9 kDa
Purity:
≥ 95%

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Data and Publications

Data

(A) The biological activity of Mouse Recombinant RANTES (CCL5) was tested by its ability to induce chemotaxis of THP-1 cells. Cell migration was measured after 45 min using a fluorometric assay method. Increase in migration over basal level was seen starting at 10 ng/mL. (B) 1 μg of Mouse Recombinant RANTES (CCL5) was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant RANTES (CCL5) has a predicted molecular mass of 7.9 kDa.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.