Mouse Recombinant MIG (CXCL9)

Monokine induced by interferon-gamma

Mouse Recombinant MIG (CXCL9)

Monokine induced by interferon-gamma

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Monokine induced by interferon-gamma
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Overview

Monokine induced by interferon-gamma (MIG), or CXCL9, is a member of the CXC chemokine family. MIG is closely related to two other chemokines: CXCL10 and CXCL11, all of which signal through the CXCR3 receptor (Ding et al.). MIG is secreted by a variety of immune cells including T cells, NK cells, dendritic cells, macrophages, and eosinophils, as well as non-immune cells including hepatic stellate cells, preadipocytes, thyrocytes, endothelial cells, tumor cells, fibroblasts, and glial cells of the central nervous system. MIG has also been shown to act as a chemoattractant for activated T cells and for tumor-infiltrating leukocytes (TILs), but not for neutrophils or for monocytes. MIG has also been reported to be both a tumor suppressor and tumor promoter in various types of cancer.
Subtype
Cytokines
Cell Type
Monocytes, T Cells
Species
Mouse
Area of Interest
Immunology
Purity
≥ 95%

Data Figures

(A) The biological activity of Mouse Recombinant MIG (CXCL9) was tested using a Ca2+ mobilization assay in CHO-K1 cells stably expressing Gα15 and CXCR3. Calcium mobilization was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which calcium mobilization is at 50% of maximum. The EC50 in the example above is less than 2 μg/mL. (B) 2 μg of Mouse Recombinant MIG (CXCL9) was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant MIG (CXCL9) has a predicted molecular mass of 12.3 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78177.1, 78177
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78177.1, 78177
Lot #
All
Language
English

Applications

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