Mouse Recombinant IL-33

Interleukin 33

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Mouse Recombinant IL-33

Interleukin 33

From: 206 USD

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Interleukin 33

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Overview

Interleukin 33 (IL-33) is a pro-inflammatory cytokine from the IL-1 family. It binds to the ST2 receptor and activates NF-kB and MAPK pathways. IL-33 is expressed by epithelial cells, smooth muscle cells, and fibroblasts in various tissues and organs, as well as resting basophils, mast cells, eosinophils, natural helper cells, group 2 innate lymphoid cells, dendritic cells, and activated macrophages (Schmitz et al.; Yasuda et al.). It contributes to allergic inflammation by stimulating production of the cytokines IL-4, IL-5, and IL-13 in Th2 cells, and stimulates host defense against microbial and viral infections (Liew; Yasuda et al.). In the central nervous system, IL-33 is produced by endothelial cells and astrocytes. It induces proliferation of microglia and mediates production of pro-inflammatory cytokines (Yasuoka et al.).

Cytokines

IL-1F11, Interleukin-33

Monocytes, T Cells, Other Subsets

Mouse

Immunology

> 95%

Data Figures

(A) The biological activity of Mouse Recombinant IL-33 was tested by its ability to promote the proliferation of D10S cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.47 ng/mL.
(B) 5 μg of Mouse Recombinant IL-33 was resolved with SDS-PAGE under reducing (+) conditions and visualized by Coomassie Blue staining. Mouse Recombinant IL-33 has a predicted molecular mass of 17.5 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type

Product Name

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Document Type

Product Information Sheet

Product Name

Mouse Recombinant IL-33

Catalog #

78044.1, 78044

Lot #

All

Language

English

Document Type

Safety Data Sheet

Product Name

Mouse Recombinant IL-33

Catalog #

78044.1, 78044

Lot #

All

Language

English

Resources and Publications

Related Products

Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.

Mouse Recombinant IL-33

Interleukin 33

Mouse Recombinant IL-33

Interleukin 33

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Overview

Data Figures

Protocols and Documentation

Resources and Publications

Educational Materials (3)

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