Mouse Recombinant IL-1 alpha

Interleukin 1 alpha
Catalog #
78129_C
Interleukin 1 alpha
From: 757 USD

Overview

Interleukin 1 alpha (IL-1α) is a member of the IL-1 family and a dual-function cytokine. Both the unprocessed precursor and a processed IL-1α protein signal through IL-1 receptor type 1 (IL-1R1). Various cells, including keratinocytes, thymic epithelium, hepatocytes, endothelial cells, fibroblasts, and the epithelial cells of mucous membranes have high levels of intracellular IL-1α precursor, which is also expressed on the surface of monocytes and B lymphocytes (Netea et al.). IL-1α recruits infiltrating cells to a site of injury during necrosis and plays an important role during processes of sterile inflammation (Rider et al.; Cohen et al.). During hypoxia, IL-1α contributes to angiogenesis (Carmi et al.). IL-1α is produced by microglia-like cells after ischemic brain injury, which contributes to the inflammation (Luheshi et al.).
Subtype
Cytokines
Alternative Names
BAF, B-cell-activating factor, Epidermal cell-derived thymocyte-activating factor, ETAF, FAF, Fibroblast-activating factor, IL-1F1, LAF, LEM, Leukocyte endogenous mediator, Lymphocyte-activating factor, MCF, Mononuclear cell factor
Cell Type
Angiogenic Cells, B Cells, Endothelial Cells, Epithelial Cells, Macrophages, Monocytes, Neural Stem and Progenitor Cells
Area of Interest
Angiogenic Cell Research, Endothelial Cell Biology, Epithelial Cell Biology, Immunology
Molecular Weight
18.1 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Mouse Recombinant IL-1 alpha
Catalog #
78129.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Mouse Recombinant IL-1 alpha
Catalog #
78129.1
Lot #
All
Language
English

Educational Materials (8)

Brochure
Tools For Your Immunology Research
Brochure
Cytokines, Chemokines and Growth Factors
Wallchart
Identification of Colonies Derived from Human Hematopoietic Progenitors
Wallchart
Frequencies of Cell Types in Human Peripheral Blood
Wallchart
Human Immune Cytokines
Video
Cell Isolation Directly from Whole Blood without RBC Lysis or Centrifugation: EasySep™ Direct
1:44
Cell Isolation Directly from Whole Blood without RBC Lysis or Centrifugation: EasySep™ Direct
Webinar
New Tools for the Ex Vivo Expansion of Human Hematopoietic Stem and Progenitor Cells
1:06:52
New Tools for the Ex Vivo Expansion of Human Hematopoietic Stem and Progenitor Cells
Mini Review
Hematopoietic Stem and Progenitor Cells (HSPCs): Isolation, Culture, and Assays

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Mouse Recombinant IL-1 alpha was tested by its ability to promote the proliferation of D10.G4.1 cells. Cell proliferation was measured after 72 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. The EC50 in the example above is 0.00581 ng/mL. (B) 1 μg of Mouse Recombinant IL-1 alpha was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

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