Mouse Recombinant IGF-II

Insulin-like growth factor 2

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Insulin-like growth factor 2
From: 75 USD

Overview

Insulin-like growth factor 2 (IGF-II) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-II binding to IGF-I receptor activates a signaling cascade via the MAPK and PI3K pathways. IGF-II affects growth, differentiation, and survival of cells in a variety of tissues during embryonic development. It stimulates proliferation and migration of primary lymphatic endothelial cells, and induces lymphangiogenesis (Guvakova).
Alternative Names:
Insulin-like growth factor type 2, Insulin-like growth factor II, Somatomedin A, T3M-11-derived growth factor
Cell Type:
Hematopoietic Stem and Progenitor Cells; Neural Cells, PSC-Derived; Neural Stem and Progenitor Cells; Neurons; Prostate Cells
Species:
Mouse
Area of Interest:
Epithelial Cell Biology; Neuroscience; Stem Cell Biology
Molecular Weight:
7.4 kDa
Purity:
≥ 95%

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Data

(A) The biological activity of Mouse Recombinant IGF-II was tested by its ability to promote the proliferation of FDC-P1 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 32 ng/mL. (B) 1 μg of Mouse Recombinant IGF-II was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant IGF-II has a predicted molecular mass of 7.4 kDa.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.