Mouse Recombinant IGF-I

Insulin-like growth factor 1

More Views

From: 82 USD

Options

* Required Fields

Catalog # (Select a product)
Insulin-like growth factor 1
From: 82 USD

Overview

Insulin-like growth factor 1 (IGF-I) is a polypeptide which belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway; it also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang et al.). Together with interleukin 3 (IL-3), IGF-I stimulates differentiation and proliferation of myeloid cells, and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk et al.).
Alternative Names:
IBP1, IGF-IA, IGF-IB, IGF1A, Mechano growth factor, MGF, Somatomedin C
Cell Type:
Neural Cells, PSC-Derived; Neural Stem and Progenitor Cells; Prostate Cells
Species:
Mouse
Area of Interest:
Epithelial Cell Biology; Neuroscience; Stem Cell Biology
Molecular Weight:
7.8 kDa
Purity:
≥ 95%

Scientific Resources

Product Documentation

Document Type
Product Name
Catalog #
Lot #
Language

Educational Materials

(2)

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Mouse Recombinant IGF-I was tested by its ability to promote the proliferation of FDC-P1 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 10 ng/mL. (B) 2 μg of Mouse Recombinant IGF-I was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant IGF-I has a predicted molecular mass of 7.8 kDa.

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.