LRRK2-IN-1

Inhibits LRRK2

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LRRK2-IN-1

Inhibits LRRK2

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5 mg

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Inhibits LRRK2

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Overview

LRRK2-IN-1 is an ATP-competitive inhibitor that inhibits leucine-rich repeat kinase 2 (LRRK2) and doublecortin-like kinase 1 (DCLK1; IC50 = 13 nM and 2.6 nM, respectively; Deng et al.; Weygant et al.). LRRK2 is a multi-domain protein kinase that regulates a wide range of cellular processes such as homeostasis and cell survival (Funk et al.). Mutations in LRRK2 that increase its kinase activity have a strong association with the development of Parkinson’s disease (Rui et al.).

CANCER RESEARCH
· Inhibits cell proliferation and migration in colorectal and pancreatic cancer (Weygant et al.).
DISEASE MODELING
· Inhibits the activity of LRRK2 kinase and stimulates macroautophagy in human neuroglioma cells (Manzoni et al.).

Leucine-rich repeat kinase 2 IN-1

Neurons

Cancer, Disease Modeling, Neuroscience

1234480-84-2

C31H38N8O3

570.7 g/mol

≥ 95%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

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Product Information Sheet

Product Name

LRRK2-IN-1

Catalog #

100-0896

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All

Language

English

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Safety Data Sheet

Product Name

LRRK2-IN-1

Catalog #

100-0896

Lot #

All

Language

English

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LRRK2-IN-1

Inhibits LRRK2

LRRK2-IN-1

Inhibits LRRK2

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Overview

Protocols and Documentation

Resources and Publications

Educational Materials (4)

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