· Direct lineage reprogramming of fibroblasts to mature neurons, in combination with CHIR99021, Forskolin , SB431542, and I-BET151 (Li et al.).
· Induces neuronal differentiation in the HCN hippocampal neural stem/progenitor cell line from adult rat, in whole brain or subventricular zone neural progenitor cells from adult mice, and in P19 embryonic carcinoma cells (Schneider et al.).
· Improves hippocampal neurogenesis and function in mice (Petrik et al.).
· Stimulates cardiac muscle gene expression and cell cycle activity in adult mouse myocardium (Russell et al.).
· Blocks tumor cell proliferation and induces neuronal gene expression in malignant astrocytes (Zhang et al.).
· Improves β-cell function, increases expression of transcription factors that enhance β-cell differentiation and increases intracellular insulin content in primary human islet cultures (Dioum et al.).
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