Hydroxychloroquine

Inhibits autophagy and heme polymerase

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Inhibits autophagy and heme polymerase
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Overview

Hydroxychloroquine is a synthetic derivative of quinolyl. It increases the pH within intracellular vacuoles and alters processes such as protein degradation by acidic hydrolases, assembly of macromolecules, and post-translation modification of proteins (Fox). By doing this, it prevents the stimulation of CD4+ cells, thus down-regulating the immune response (Fox). Hydroxychloroquine is also a potent autophagy inhibitor (van Loosdregt et al.) and heme polymerase inhibitor (Chou & Fitch). This product is supplied as the sulfate salt of the molecule.


IMMUNOLOGY
· Inhibits the survival pathway of autophagy by preventing the degradation of autophagosomes, resulting in increased apoptosis of human CD4+CD45RO+ memory and effector T cells (van Loosdregt et al.).

CANCER RESEARCH
· In combination with various other treatments, increases the overall response rate, progression-free survival, and 1-year overall survival rate of cancer therapies (for glioblastoma, brain metastases due to non-small-cell lung cancer and breast cancer, pancreatic ductal adenocarcinoma [PDAC], non-Hodgkin lymphoma, metastatic PDAC, and pancreatic cancer), when compared to cancer therapies that do not utilize autophagy inhibition (Xu et al.).
Alternative Names:
HCQ; NSC 4375
CAS Number:
747-36-4
Chemical Formula:
C₁₈H₂₆ClN₃O • H₂SO₄
Molecular Weight:
434.0 g/mol
Purity:
≥ 95%

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This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.