Human Recombinant Persephin, ACF

Persephin, animal component-free

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Persephin, animal component-free
From: 167 USD

Overview

Persephin is a neurotrophic factor that belongs to the glial cell line-derived neurotrophic factor (GDNF) family. Persephin shares a large degree of structural similarity to GDNF, artemin, and neurturin, and has overall neuroprotective activity. Persephin signals through GRFα4 (glycosylphosphatidylinositol (GPI)-linked GDNF receptor family member) which signals through the receptor tyrosine kinase RET. Unlike GDNF and neurturin, persephin only promotes the growth and survival of central dopaminergic and motor neurons, but not peripheral neurons (Milbrandt et al.). In vitro persephin only promotes survival of neurons that co-express GPI-linked GRFα4 and RET (Enokido et al.; Lindahl et al.). Mice lacking persephin showed increased cell death after cerebral ischemia, however administration of persephin before ischemia dramatically reduced neuronal cell death (Tomac et al.). This product is animal component-free.
Alternative Names:
PSP, PSPN
Cell Type:
Neurons
Species:
Human
Area of Interest:
Neuroscience
Molecular Weight:
10.4 kDa monomer; 20.8 kDa dimer
Purity:
≥ 95%

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Data

(A) The biological activity of Human Recombinant Persephin, ACF was tested by its ability to promote the proliferation of TT cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the neurotrophic factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is 2.27 ng/mL. (B) 1 μg of Human Recombinant Persephin, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant Persephin, ACF has a predicted molecular mass of 20.8 kDa (10.4 kDa per monomer).

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.