Human Recombinant NOV

Nephroblastoma overexpressed gene protein

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Nephroblastoma overexpressed gene protein
From: 94 USD

Overview

Neuroblastoma overexpressed gene protein (NOV) is a member of the CCN (CYR61/CTGF/NOV) family. NOV contains four structural domains: a non-functional N-terminal insulin-like growth factor-binding protein (IGFBP) domain, a von Willebrand factor C (vWFC) domain that mediates oligomerization, a thrombospondin type I domain that mediates matrix interactions, and a C-terminal cysteine knot domain that interacts with fibulin 1C, Notch1, and CCN2 (Perbal 2004; Perbal 2006; Perbal et al.; Sakamoto et al.). NOV interacts with integrins αVβ3 and α5β1 to mediate adhesion of endothelial cells, chemotaxis, and angiogenesis (Lin et al.). It also interacts with gap junction protein connexin43 to suppress cell proliferation (Fu et al.). During development, NOV is expressed in multiple tissues including: muscle, endothelium, nervous system, adrenal cortex, and chondrocytes (Martinerie et al.; Perbal 2004; Perbal 2006; Snaith et al.). In cancers expressing the N-terminally truncated version, NOV localizes to the nucleus and promotes proliferation (Planque et al.).
Alternative Names:
CCN3, CCN family member 3, IBP-9, IGF-binding protein 9, IGFBP-9, Insulin-like growth factor-binding protein 9, Nephroblastoma-overexpressed gene protein homolog, NovH, Protein NOV homolog
Cell Type:
Chondrocytes; Endothelial Cells; Neurons
Species:
Human
Area of Interest:
Endothelial Cell Biology
Molecular Weight:
35.7 kDa
Purity:
≥ 95%

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Data and Publications

Data

(A) The biological activity of Human Recombinant NOV was tested by its ability to promote the proliferation of 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the protein at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 5 μg/mL. (B) 2 μg of Human Recombinant NOV was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant NOV has a predicted molecular mass of 35.7 kDa.

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