Human Recombinant IL-33

Interleukin 33

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Interleukin 33
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Overview

Interleukin 33 (IL-33) is a pro-inflammatory cytokine from the IL-1 family. It binds to ST2 receptor and activates NF-κB and MAPK pathways. IL-33 is expressed by epithelial cells, smooth muscle cells, and fibroblasts in various tissues and organs, as well as resting basophils, mast cells, eosinophils, natural helper cells, group 2 innate lymphoid cells, dendritic cells, and activated macrophages (Schmitz et al.; Yasuda et al.). It contributes to allergic inflammation by stimulating production of the cytokines IL-4, IL-5, and IL-13, and stimulates host defense against microbial and viral infections (Liew; Yasuda et al.). In the central nervous system, IL-33 is produced by endothelial cells and astrocytes. It induces proliferation of microglia and mediates production of pro-inflammatory cytokines (Yasuoka et al.).
Alternative Names:
IL-1F11, Interleukin-33, NP-HEV
Cell Type:
Monocytes; T Cells, Other Subsets
Species:
Human
Area of Interest:
Immunology
Molecular Weight:
18.1 kDa
Purity:
≥ 95%

Scientific Resources

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(3)

Data and Publications

Data

(A) The biological activity of Human Recombinant IL-33 was tested by its ability to promote the proliferation of D10S cells in low serum medium containing no other cytokines. Cell proliferation was measured after 67 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.1 - 0.15 ng/mL.
(B) 1 μg of Human Recombinant IL-33 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-33 has a predicted molecular mass of 18.1 kDa.

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