Human Recombinant IL-1 alpha, ACF

Interleukin 1 alpha, animal component-free

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Interleukin 1 alpha, animal component-free
From: 204 USD

Overview

Interleukin 1 alpha (IL-1α) is a member of the IL-1 family and is a dual-function cytokine. Both the unprocessed precursor and a processed IL-1α protein signal through IL-1 receptor type 1 (IL-1R1). Various cells, including keratinocytes, thymic epithelium, hepatocytes, endothelial cells, fibroblasts, and the epithelial cells of mucous membranes, have high levels of intracellular IL-1α precursor. The precursor is also expressed on the surface of monocytes and B lymphocytes (Netea et al.). IL-1α recruits infiltrating cells to a site of injury during necrosis and plays an important role during processes of sterile inflammation (Cohen et al.; Rider et al.). During hypoxia, IL-1α contributes to angiogenesis (Carmi et al.). Studies in mice show that IL-1α is produced by microglia-like cells after ischemic brain injury, which contributes to inflammation (Luheshi et al.). This product is animal component-free.
Alternative Names:
BAF, B-cell-activating factor, Epidermal cell-derived thymocyte-activating factor, ETAF, FAF, Fibroblast-activating factor, IL-1F1, LAF, LEM, Leukocyte endogenous mediator, Lymphocyte-activating factor, MCF, Mononuclear cell factor
Cell Type:
B Cells; Monocytes; T Cells
Species:
Human
Area of Interest:
Immunology
Molecular Weight:
18.0 kDa
Purity:
≥ 95%

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Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant IL-1 alpha, ACF was tested by its ability to promote the proliferation of D10.G4.1 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 7.7 pg/mL. (B) 1 μg of Human Recombinant IL-1 alpha, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-1 alpha, ACF has a predicted molecular mass of 18.0 kDa.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.