• Compare Products
Menu
Account
Explore the new wish list functionality on our website, which lets you organize products into wish lists, view your saved products, and share them with others. Sign in or create an account to access this feature. Explore the new wish list functionality on our website. Sign in or create an account to access this feature.

Human Recombinant IHH

Indian hedgehog

Loading...
 

Human Recombinant IHH

Indian hedgehog

From: 147 USD
Catalog #
(Select a product)
Indian hedgehog
Add to Wish List

Overview

Indian hedgehog (IHH) is one of three proteins in the hedgehog family which includes sonic hedgehog and desert hedgehog. Hedgehog proteins are important signaling molecules, acting through patched and smoothened receptors. During embryonic development, they are expressed in the fetal lung, gut, stomach, liver, kidney, and pancreas. IHH is strongly expressed in cartilage and regions of developing bone, and its signaling regulates growth and differentiation of bone tissue (Marigo et al.; Valentini et al.; St-Jacques et al.). IHH is also involved in yolk sac vasculogenesis, indicating a role in the differentiation of epiblast cells into endothelial and red blood cells (Byrd et al.). IHH induces the expression of parathyroid hormone-related peptide (PTHrP), which negatively regulates IHH during chondrocyte differentiation and proliferation (Vortkamp et al.).
Subtype
Cytokines
Cell Type
Endothelial Cells, Mesenchymal Stem and Progenitor Cells, Red Blood Cells
Species
Human
Area of Interest
Endothelial Cell Biology, Stem Cell Biology
Purity
≥ 95%

Data Figures

(A) The biological activity of Human Recombinant IHH was tested by its ability to induce alkaline phosphatase activity by CCL-226 cells. Alkaline phosphatase activity was measured by a fluorometric assay method. The EC50 is defined as the effective concentration of the signaling molecule at which alkaline phosphatase activity is at 50% of maximum. The EC50 in the example above is less than 3 μg/mL. (B) 2 μg of Human Recombinant IHH was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IHH has a predicted molecular mass of 19.7 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant IHH
Catalog #
78197, 78197.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IHH
Catalog #
78197, 78197.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (4)

Reliable Antibodies for Your Research
Brochure
Reliable Antibodies for Your Research
Cytokines, Chemokines and Growth Factors
Brochure
Cytokines, Chemokines and Growth Factors
Directed Differentiation of Pluripotent Stem Cells
Wallchart
Directed Differentiation of Pluripotent Stem Cells
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research

Related Products

Related Products

Quality Statement:

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.

Copyright © 2024 by STEMCELL Technologies. All rights reserved.