Human Recombinant GDF-11, ACF

Growth differentiation factor 11, animal component-free

More Views

From: 167 USD

Options

* Required Fields

Catalog # (Select a product)
Growth differentiation factor 11, animal component-free
From: 167 USD

Overview

Growth differentiation factor 11 (GDF-11) is a member of transforming growth factor beta (TGF-β) family. It binds to the TGF-β receptors ALK4, ALK5, and ALK7 and activates the SMAD signaling pathway (Ho et al.). GDF-11 regulates the development of the olfactory system, retina, and pancreas, as well as anterior/posterior patterning of the axial skeleton (Lee & Lee). GDF-11 is an endocrine factor expressed in skeletal muscle, brain, and dental pulp (Kondás et al.). Studies in mice showed that GDF-11 regulates muscle and cardiac aging, and stimulates neurogenesis by remodeling blood vessels (Katsimpardi et al.; Loffredo et al.; Sinha et al.). This product is animal component-free.
Alternative Names:
BMP-11, Bone morphogenetic protein 11, Growth/differentiation factor 11
Cell Type:
Neural Cells, PSC-Derived
Species:
Human
Area of Interest:
Stem Cell Biology; Neuroscience
Molecular Weight:
12.5 kDa monomer; 24.9 kDa dimer
Purity:
≥ 95%

Scientific Resources

Product Documentation

Document Type
Product Name
Catalog #
Lot #
Language

Educational Materials

(5)

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant GDF-11, ACF was tested by its ability to induce alkaline phosphatase activity in ATDC5 cells. Alkaline phosphatase activity was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which alkaline phosphatase activity is at 50% of maximum. The EC50 in the example above is 3.54 ng/mL. (B) 1 μg of Human Recombinant GDF-11, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant GDF-11, ACF has a predicted molecular mass of 24.9 kDa (12.5 kDa per monomer).

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.