Human Recombinant FGF-8B, ACF

Fibroblast growth factor 8B, animal component-free

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Fibroblast growth factor 8B, animal component-free
From: 206 USD

Overview

Fibroblast growth factor 8B (FGF-8B) is a member of the fibroblast growth factor (FGF) family and is an isoform of FGF-8. Cytokines in the FGF family possess broad mitogenic and cell survival activities (Folkman & Klagsbrun; Kimelman & Kirschner) and are involved in a variety of biological processes, including cell proliferation, differentiation, survival, and apoptosis (Folkman & Klagsbrun; Klagsbrun; Rifkin & Moscatelli). FGF-8B signals through FGF receptors (FGFRs) to activate PI3K and MAPK pathways. FGF-8B regulates gastrulation, epithelial-mesenchymal transition, and mesenchymal to epithelial differentiation during embryonic development. FGF-8B has also been found in peripheral blood leukocytes and healthy bone marrow samples (Mattila & Härkönen). FGF-8B has mitogenic effects on somatic cells in the germinal epithelium and is expressed in adult mouse ovarian cells and tissues, which suggests that it regulates maturation of oocytes and seminiferous epithelium in testes (Valve et al.). This product is animal component-free.
Alternative Names:
AIGF, Androgen-induced growth factor, FGF-8, Fibroblast growth factor-8B, HBGF-8, Heparin-binding growth factor-8
Cell Type:
Endoderm, PSC-Derived; Hematopoietic Stem and Progenitor Cells; Neural Cells, PSC-Derived; Pluripotent Stem Cells
Species:
Human
Area of Interest:
Epithelial Cell Biology; Neuroscience; Stem Cell Biology
Molecular Weight:
22.5 kDa
Purity:
≥ 95%

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Data and Publications

Data

(A) The biological activity of Human Recombinant FGF-8B, ACF was tested by its ability to promote the proliferation of NR6R 3T3 cells in the presence of heparin. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is 0.915 ng/mL. (B) 1 μg of Human Recombinant FGF-8B, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-8B, ACF has a predicted molecular mass of 22.5 kDa.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.