Human Recombinant Cardiotrophin-1

Cardiotrophin 1

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Cardiotrophin 1
From: 186 USD

Overview

Cardiotrophin-1 is a member of the IL-6 (interleukin 6) cytokine family that includes IL-6, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). Cardiotrophin-1 is a pleiotropic cytokine with activity that overlaps with other IL-6 family members. Cardiotrophin-1 is expressed in various tissues including heart, skeletal muscle, liver, lung, kidney, ovary, colon, and prostate. It initiates downstream signaling pathways through the heterodimerization of gp130 and the LIF receptor β subunit (Pennica et al.; Robledo et al.). Binding of cardiotrophin-1 initiates signaling through the JAK/STAT, MEK/ERK, and AKT pathways. Cardiotrophin-1 has been shown to have cardioprotective and neuroprotective effects. It has also been shown to promote cardiomyocyte survival and plays an essential role in the development of neural tissue (López-Yoldi et al.).
Alternative Names:
CT-1, CTF1
Cell Type:
Cardiomyocytes, PSC-Derived; Hepatic Cells; Prostate Cells
Species:
Human
Area of Interest:
Stem Cell Biology
Molecular Weight:
21.1 kDa
Purity:
≥ 95%

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Data and Publications

Data

(A) The biological activity of Human Recombinant Cardiotrophin-1 was tested by its ability to promote the proliferation of TF-1 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 0.4 ng/mL. (B) 2 μg of Human Recombinant Cardiotrophin-1 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant Cardiotrophin-1 has a predicted molecular mass of 21.1 kDa.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.