Human Recombinant BMPR-1A Fc

Bone morphogenetic protein receptor type 1A, Fc tag

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Bone morphogenetic protein receptor type 1A, Fc tag
From: 225 USD

Overview

Bone morphogenetic protein receptor type 1A (BMPR-1A) is a type I receptor of the BMP receptor family of transmembrane serine/threonine kinases (Abe; Fischerauer et al.); it is also known as ALK3. BMPR-1A is a receptor for BMP-2, BMP-4, GDF-5, and GDF-6. Binding of BMPs to receptor complexes results in phosphorylation of intracellular SMADs, which go on to regulate transcription (Pan et al.). BMP regulation plays a role in proliferation, differentiation, migration, and apoptosis of endothelial and vascular smooth muscle cells (Abe). BMPR-1A deficiency is lethal during gastrulation (Mishina et al.). BMPR-1A is important in chondrogenesis and osteogenesis, along with BMPR-1B (Fischerauer et al.; Jing et al.). This protein contains a C-terminus linker (IEGRMD) to an Fc tag (Human IgG1).
Alternative Names:
Activin receptor-like kinase 3, ACVRLK3, ALK3, BMP type-1A receptor, BRK‐1, CD292, Serine/threonine-protein kinase receptor R5, SKR5
Cell Type:
Chondrocytes; Endoderm, PSC-Derived; Endothelial Cells; Mesenchymal Stem and Progenitor Cells; Mesoderm, PSC-Derived; Osteoblasts; Pluripotent Stem Cells; Smooth Muscle
Species:
Human
Area of Interest:
Cancer Research; Stem Cell Biology
Molecular Weight:
40.4 kDa monomer; 80.8 kDa dimer
Purity:
≥ 95%

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Data

The biological activity of Human Recombinant BMPR-1A Fc was tested by its ability to inhibit BMP-4-induced alkaline phosphatase production in ATDC-5 cells. Inhibition of BMP-4-induced alkaline phosphatase production was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which inhibition of alkaline phosphatase production is at 50% of maximum. The EC50 in the above example is 61.5 ng/mL.

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