Human Amyloid-β (1-42) Peptide (Trifluoroacetate Salt)
Neurotoxic peptide fragment
Human Amyloid-β (1-42) Peptide (Trifluoroacetate Salt)
Neurotoxic peptide fragment
Overview
Human Amyloid-β (1-42) Peptide is a neurotoxic peptide fragment that can oligomerize to form amyloid plaques, thus contributing to the onset of Alzheimer's disease (Paradis et al.; Teplow; Wolfe). These neurotoxic peptide fragments also modulate the expression of Bcl-2 and Bax in human neurons (Paradis et al.).
NOTE: Human Amyloid-β (1-42) Peptide oligomers and fibrils are considered neurotoxic. Please contact your workplace safety committee for guidance before planning any work using Human Amyloid-β (1-42) Peptide.
DISEASE MODELING
· Induces neuronal death in human neurons in vitro and in vivo (Paradis et al.).
· Increases production of TNF-α in rat astrocytes (Hughes et al.).
NOTE: Human Amyloid-β (1-42) Peptide oligomers and fibrils are considered neurotoxic. Please contact your workplace safety committee for guidance before planning any work using Human Amyloid-β (1-42) Peptide.
DISEASE MODELING
· Induces neuronal death in human neurons in vitro and in vivo (Paradis et al.).
· Increases production of TNF-α in rat astrocytes (Hughes et al.).
Alternative Names
Aβ (1-42); Aβ42
Cell Type
Neurons
Area of Interest
Disease Modeling, Neuroscience
Purity
≥ 95 %
Related Products
Related Products
Scientific Resources
Product Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Educational Materials (3)
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
