Human Amyloid-β (1-42) Peptide (Trifluoroacetate Salt)
Neurotoxic peptide fragment
Overview
Human Amyloid-β (1-42) Peptide is a neurotoxic peptide fragment that can oligomerize to form amyloid plaques, thus contributing to the onset of Alzheimer's disease (Paradis et al.; Teplow; Wolfe). These neurotoxic peptide fragments also modulate the expression of Bcl-2 and Bax in human neurons (Paradis et al.).
NOTE: Human Amyloid-β (1-42) Peptide oligomers and fibrils are considered neurotoxic. Please contact your workplace safety committee for guidance before planning any work using Human Amyloid-β (1-42) Peptide.
DISEASE MODELING
· Induces neuronal death in human neurons in vitro and in vivo (Paradis et al.).
· Increases production of TNF-α in rat astrocytes (Hughes et al.).
NOTE: Human Amyloid-β (1-42) Peptide oligomers and fibrils are considered neurotoxic. Please contact your workplace safety committee for guidance before planning any work using Human Amyloid-β (1-42) Peptide.
DISEASE MODELING
· Induces neuronal death in human neurons in vitro and in vivo (Paradis et al.).
· Increases production of TNF-α in rat astrocytes (Hughes et al.).
Alternative Names
Aβ (1-42); Aβ42
Cell Type
Neurons
Area of Interest
Disease Modeling, Neuroscience
Purity
≥ 95 %
Related Products
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Scientific Resources
Product Documentation
| Document Type | Product Name | Catalog # | Lot # | Language |
|---|---|---|---|---|
|
Document Type
Product Information Sheet
|
Product Name
Human Amyloid-β (1-42) Peptide (Trifluoroacetate Salt)
|
Catalog #
100-0899 |
Lot #
All |
Language
English |
|
Document Type
Safety Data Sheet
|
Product Name
Human Amyloid-β (1-42) Peptide (Trifluoroacetate Salt)
|
Catalog #
100-0899 |
Lot #
All |
Language
English |
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