GSK621

AMPK agonist

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AMPK agonist
From: 75 USD

Overview

GSK621 is a specific agonist of AMP-activated protein kinase (AMPK; Sujobert et al.)

CANCER RESEARCH
· Increases AMPKα T172 phosphorylation, a marker of AMPK activation, in acute myeloid leukemia (AML) cells and primary AML samples (Sujobert et al.).
· Displays selective cytotoxicity (IC₅₀ = 13 - 30 μM) by activating autophagy via the eIF2ɑ signaling pathway independent of mTORC1 activation in AML cell lines but not in normal hematopoietic progenitor cells (Sujobert et al.).
· Inhibits human melanoma cell survival and proliferation (Chen et al.).
CAS Number:
1346607-05-3
Chemical Formula:
C₂₆H₂₀ClNO
Molecular Weight:
489.9 g/mol
Purity:
≥ 98%
Pathway:
AMPK
Target:
AMPK

Scientific Resources

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