Diseased Human Peripheral Blood Products, Type I Interferonopathy

Primary human cells, fresh or frozen

Diseased Human Peripheral Blood Products, Type I Interferonopathy

Primary human cells, fresh or frozen

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Primary human cells, fresh or frozen
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Product Advantages


  • Get large numbers of diseased cells at a given time point from a single-donor

  • Obtain PBMCs and a range of immune cell subsets from a single leukopak

  • Allow for flexibility in your workflow by being able to freeze cells for future experiments

Overview

Start your research confidently with a reliable supply of ethically sourced peripheral blood (PB) products from donors diagnosed with Type I Interferonopathies, a group of autoimmune and autoinflammatory disorders caused by certain genetic mutations which enhance active type I interferons (IFN) expression in the body. Cells from donors may be used to identify pathway targets for therapies. Product options include fresh leukopaks, frozen mononuclear cells (MNCs or PBMCs), and plasma. Additional product options, including frozen leukopaks and other custom sizes, can also be requested through this form. We help you get the cells you need with personalized service and flexible delivery times.

Leukopaks are an enriched leukapheresis product consisting of a large number of single-donor MNCs, collected using the Spectra Optia® Apheresis System, with acid-citrate-dextrose solution A (ACDA) as the anticoagulant. Primary human MNCs are isolated from PB leukapheresis samples using density gradient separation or red blood cell lysis and cryopreserved in animal component-free CryoStor®CS10 medium (Catalog #07930). All PB products are obtained from donors diagnosed with Type I Interferonopathies, confirmed by the collection facility Medical Director, using Institutional Review Board (IRB)-approved consent forms and protocols. Additional documentation, donor disease and treatment information, and high-resolution HLA typing (Class I and Class II alleles) may be available upon request. Donor specifications (e.g. BMI category, age, ethnicity, etc.) can be requested in the comment box above, after selecting from the product options. Donors are screened for HIV-1, HIV-2, hepatitis B, and hepatitis C.

Certain products are only available in select territories. Please contact your local sales representative or Product & Scientific Support at techsupport@stemcell.com for further information.
Contains
• CryoStor® CS10
Subtype
Fresh, Frozen
Cell Type
Leukopaks, Mononuclear Cells, Plasma, T Cells
Species
Human
Cell and Tissue Source
Peripheral Blood, Plasma
Application
Activation, Cell Culture, Cell Isolation, Cryopreservation, Expansion, Genome Editing, Toxicity Assay
Area of Interest
Disease Modeling, Drug Discovery and Toxicity Testing
Donor Status
Diseased - Autoimmune & Inflammatory

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
200-0864
Lot #
All
Language
English
Catalog #
200-0823, 200-0839
Lot #
All
Language
English