CP-945,598 (Hydrochloride)

CB1 receptor antagonist

CP-945,598 (Hydrochloride)

CB1 receptor antagonist

CP-945,598 (Hydrochloride)
10 mg
215 USD
Catalog # 100-0898

CB1 receptor antagonist

Overview

CP-945,598 is a selective cannabinoid type 1 (CB1) receptor antagonist (Ki = 0.7 nM) and exhibits low affinity for CB2 receptors (Ki = 7.6 µM; Hadcock et al.). Cannabinoid receptors are part of the G protein-coupled receptor (GPCR) superfamily, and CB1 receptors are abundant in the brain and are able to attenuate neurotransmission (Mackie). Endocannabinoid system signaling components are expressed in the basal ganglia and interact with both GABA and dopaminergic signaling pathways. Modulation of CB1 is a potential therapeutic target for Parkinson’s disease (Han et al.).

METABOLISM
· Alters fat oxidation and energy expenditure in rats (Hadcock et al.).
Alternative Names
Otenabant
Cell Type
Neurons
Area of Interest
Disease Modeling, Neuroscience
CAS Number
686347-12-6
Chemical Formula
C25H25Cl2N7O • HCl
Molecular Weight
546.9
Purity
≥ 98%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-0898
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-0898
Lot #
All
Language
English

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