CP-945,598 (Hydrochloride)

CB1 receptor antagonist
CP-945,598 (Hydrochloride)

CB1 receptor antagonist

10 mg
Catalog # 100-0898
215 USD

Overview

CP-945,598 is a selective cannabinoid type 1 (CB1) receptor antagonist (Ki = 0.7 nM) and exhibits low affinity for CB2 receptors (Ki = 7.6 µM; Hadcock et al.). Cannabinoid receptors are part of the G protein-coupled receptor (GPCR) superfamily, and CB1 receptors are abundant in the brain and are able to attenuate neurotransmission (Mackie). Endocannabinoid system signaling components are expressed in the basal ganglia and interact with both GABA and dopaminergic signaling pathways. Modulation of CB1 is a potential therapeutic target for Parkinson’s disease (Han et al.).

METABOLISM
· Alters fat oxidation and energy expenditure in rats (Hadcock et al.).
Alternative Names
Otenabant
Cell Type
Neurons
Area of Interest
Disease Modeling, Neuroscience
CAS Number
686347-12-6
Chemical Formula
C25H25Cl2N7O • HCl
Molecular Weight
546.9
Purity
≥ 98%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
CP-945,598 (Hydrochloride)
Catalog #
100-0898
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
CP-945,598 (Hydrochloride)
Catalog #
100-0898
Lot #
All
Language
English

Educational Materials (3)

Brochure
Neural Supplements For High-Quality Neural Cell Cultures
Brochure
STEMCELL Neural Product Portfolio
Brochure
hPSC-Derived Neural Cell Research

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