Chlormethiazole (Hydrochloride)

GABAA agonist

Chlormethiazole (Hydrochloride)

GABAA agonist

From: 225 USD
Catalog #
100-0893_C
GABAA agonist

Overview

Chlormethiazole is a γ-aminobutyric acid type A (GABAA) agonist with neuroprotective and sedative properties (Cross et al.; Moody & Skolnick; Nelson et al.). The GABAA receptor consists of 5 protein subunits that span the neuronal membrane and represents the predominant inhibitory neurotransmitter in the central nervous system (Mele et al.; Nuss). Chlormethiazole also increases the chloride uptake in cortical synaptoneurosomes in a dose-dependent manner (EC50 = 48 μM; Moody & Skolnick). Chlormethiazole can restore synaptic function and correct memory defects in mouse models of neurodegeneration (Luo et al.).

DISEASE MODELING
· Protects against neuronal death in the hippocampus in gerbils (Cross et al.).
Alternative Names
Clomethiazole
Cell Type
Neurons
Area of Interest
Disease Modeling, Neuroscience
CAS Number
6001-74-7
Chemical Formula
C6H8ClNS • HCl
Molecular Weight
198.1
Purity
≥ 98%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-0893
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-0893
Lot #
All
Language
English

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