CGP77675

Src family kinases inhibitor; Inhibits Src, LCK, Yes, Cdc2, EGFR, VEGFR, v-Abl, and FAK

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Src family kinases inhibitor; Inhibits Src, LCK, Yes, Cdc2, EGFR, VEGFR, v-Abl, and FAK
From: 169 USD

Overview

CGP77675 is a potent inhibitor of Src family kinases. It has been reported to inhibit phosphorylation of peptide substrates and autophosphorylation of purified Src (IC₅₀ = 5 - 20 nM and 40 nM, respectively), Src, and Src kinase family members such as LCK (IC₅₀ = 0.02 mM and 0.29 mM, respectively). It has also been shown to inhibit epidermal growth factor receptor (EGFR), Cdc2, v-Abl, and focal adhesion kinase (FAK) (IC₅₀ = 0.15 mM, > 10 mM, 0.31 mM, and 0.2 mM, respectively; Missbach et al.).


MAINTENANCE AND SELF-RENEWAL
· In combination with the GSK3 inhibitor CHIR99021 (Catalog #72052), CGP77675 is used to maintain mouse embryonic stem (ES) cells (Shimizu et al.).

· Preserves the epigenetic and genomic integrity as well as the developmental potential of ES cells (Choi et al.).
Alternative Names:
Not applicable
CAS Number:
234772-64-6
Chemical Formula:
C₂₆H₂₉N₅O₂
Molecular Weight:
443.5 g/mol
Purity:
≥ 98%
Target:
EGFR; LCK; SRC

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This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.