Make more informed purchasing decisions with our new product availability and delivery estimate feature, now available on all product pages, in your cart, and during checkout.
Sign In
New to STEMCELL?
Register for an account to quickly and easily purchase products online and for one-click access to all educational content.
Thank you for your interest in this product.
Please provide us with your contact information and your local representative
will contact you with a customized quote. Where appropriate, they can also assist you with a(n):
Estimated delivery time for your area
Product sample or exclusive offer
In-lab demonstration
By submitting this form, you are providing your consent to STEMCELL Technologies Canada Inc. and its subsidiaries and affiliates (“STEMCELL”) to collect and use your information, and send you newsletters and emails in accordance with our privacy policy. Please contact us with any questions that you may have. You can unsubscribe or change your email preferences at any time.
Inhibit proliferation of cancer cells by inhibiting topoisomerase I activity with camptothecin. Highly potent and cell-permeable, camptothecin inhibits topoisomerase I from religating broken DNA strands by forming a complex with topoisomerase I and DNA, which leads to cell death (Thomas et al.).
Camptothecin has been used for:
CANCER RESEARCH
· Can be used as an apoptosis induction positive control (cell-type dependent) in combination with Caspase-3/7 Activity Flow Cytometry Kit, Green (Catalog #100-0923), Caspase-3/7 Activity Plate Reader Assay Kits (Catalog #100-0922/100-0920), and FITC-C6-DEVD-FMK (Catalog #100-0924).
· Demonstrates cytotoxicity against several human tumor cell lines, including HT29, LOX, SKOV3, and SKVLB (Hentze et al.).
· Promotes degradation of mixed lineage leukemia 5 (MLL5) proteins in HCT116 cells (Cheng et al.).
· Induces apoptosis in various human cancer cell lines (HeLa, K562, CCRF-CEM, HCT-15, RBE, PC3, and C-33A) via a microRNA-125b-mediated mitochondrial pathway (Zeng et al.).
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.