Atipamezole (Hydrochloride)

Selective α2-adrenergic receptor antagonist

Atipamezole (Hydrochloride)

Selective α2-adrenergic receptor antagonist

From: 185 USD
Catalog #
100-0892_C
Selective α2-adrenergic receptor antagonist

Overview

Atipamezole is an imidazole derivative and a selective α2-adrenergic receptor antagonist (Ki = 1.6 nM; Pertovaara et al.). α2-adrenergic receptor is involved in the processing of amyloid precursor protein, and is therefore a potential therapeutic target for Alzheimer's disease (Chen et al.). Atipamezole is used to reverse the sedative and analgesic effects of dexmedetomidine (Scheinin et al.), and it has also been used to assess cognitive performance of rat models in Parkinson's disease research (Haapalinna et al.).

DISEASE MODELING
· Reverses the sedative effects of α2-adrenergic receptor agonists in animals (Ewing et al.; Pertovaara et al.; Vainio & Vähä-Vahe).
· Improves the efficacy of L-DOPA and apomorphine in animals with Parkinson’s disease (Pertovaara et al.).
· Enhances the turnover of serotonin and dopamine in aged rats (Haapalinna et al.).
Area of Interest
Disease Modeling, Neuroscience
CAS Number
104075-48-1
Chemical Formula
C14H16N2 • HCl
Molecular Weight
248.8
Purity
≥ 98%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-0892
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-0892
Lot #
All
Language
English

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