Anti-SHIP2 Antibody, Polyclonal

Rabbit polyclonal antibody against human, mouse SHIP2

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Rabbit polyclonal antibody against human, mouse SHIP2
396 USD

Overview Related Products Scientific Resources Data and Publications

Overview

SHIP2 is a 145 kDa SHIP-related protein expressed in both hematopoietic and nonhematopoietic cells. Like SH2-containing inositol phosphatase (SHIP), SHIP2 becomes tyrosine phosphorylated and associated with the adaptor protein, Shc, following cytokine, growth factor, chemokine, and immunoreceptor stimulation. SHIP2 also hydrolyzes the critical phosphatidylinositol (PI)-3-kinase (PI3K)-generated second messenger, PI-3,4,5-P3 (PIP3), to PI-3,4-P2 1,2 and therefore acts as an important negative regulator of the PI3K pathway. This antibody reacts with mouse and human full-length 145 kDa SHIP2 protein.
Subtype:
Primary Antibodies
Target Antigen:
SHIP2
Alternative Names:
Inositol polyphosphate phosphatase like 1, INPPL1, OPSMD
Reactive Species:
Mouse; Human
Conjugation:
Unconjugated
Host Species:
Rabbit
Cell Type:
Granulocytes and Subsets; Lymphocytes; Myeloid Cells
Application:
Immunoblotting; Immunoprecipitation
Area of Interest:
Immunology
Clone:
Not applicable
Gene ID:
3636 (human), 16332 (mouse)
Isotype:
Not applicable

Scientific Resources

Product Documentation

Educational Materials

(2)
Brochure
Complete Antibody Listing
Wallchart
Human Immune Cytokines

Data and Publications

Data

Western blot analysis of total cell lysates (TCL) from human TF-1 cells, mouse WEHI-231 B cells, and mouse bone marrow derived mast cells (BMMCs) of SHIP +/+ and SHIP -/- mice with Anti-SHIP2 Antibody, Polyclonal (1:1000 dilution). The last two lanes represent anti-SHIP2 immunoprecipitates (IP) of 1 x 107 TF-1 cells and WEHI-231 B cells, respectively. SHIP2 has a predicted molecular mass of 145 kDa.

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