Thank you for your interest in this product.
Please provide us with your contact information and your local representative
will contact you with a customized quote. Where appropriate, they can also assist you with a(n):
Estimated delivery time for your area
Product sample or exclusive offer
In-lab demonstration
By submitting this form, you are providing your consent to STEMCELL Technologies Canada Inc. and its subsidiaries and affiliates (“STEMCELL”) to collect and use your information, and send you newsletters and emails in accordance with our privacy policy. Please contact us with any questions that you may have. You can unsubscribe or change your email preferences at any time.
The Anti-SARS-CoV Spike Protein S1 Receptor-Binding Domain Antibody, Clone D005 (Recombinant) reacts with the Spike Protein S1 receptor-binding domain (RBD) expressed by SARS-associated coronavirus (SARS-CoV) and has shown to cross-react with SARS-CoV-2 (2019-nCoV).
The Spike (S) protein is a type I transmembrane glycoprotein present on the surface of coronaviruses (CoV). Entry of CoV into host cells is mediated by the S protein, where it interacts with the cell-surface receptor angiotensin-converting enzyme 2 (ACE2). In humans, ACE2 is expressed in several organs and tissues, including intestinal and respiratory epithelium.
The S protein has two subunits, S1 and S2, where S1 primarily consists of the 193-amino acid long RBD and the N-terminal domain (NTD). The RBD binds to ACE2, making it the main target for neutralizing antibodies, while the function of the NTD is not well understood. The S2 domain is responsible for membrane fusion. During CoV infection, the S protein is cleaved into the N-terminal S1 subunit and C-terminal S2 subunit by host proteases, transforming its conformation from the pre-fusion to the post-fusion state. The S protein has been shown to play a key role in the induction of neutralizing antibody and T cell responses, which may lead to protective immunity.
Subtype
Primary Antibodies
Target Antigen
SARS-CoV Spike Protein S1 Receptor-Binding Domain
Alternative Names
SARS-CoV Spike Protein, SARS-CoV S Protein, SARS-CoV S1 Protein
Anti-SARS-CoV Spike Protein S1 Receptor-Binding Domain Antibody, Clone D005 (Recombinant)
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
