Anti-Mouse E-Cadherin (CD324) Antibody, Clone DECMA-1

Rat monoclonal IgG1 antibody against human, mouse, dog E­cadherin (CD324)
Catalog #
60157_C
Rat monoclonal IgG1 antibody against human, mouse, dog E­cadherin (CD324)
From: 162 USD

Overview

The DECMA-1 antibody recognizes E-cadherin, a calcium-dependent transmembrane glycoprotein involved in cell-cell adhesion, bacterial pathogenesis, and tumor invasion. The extracellular region of E-cadherin is composed of multiple cadherin repeats that contain calcium-binding motifs. The cytoplasmic domain of E-cadherin is reported to interact with a range of intracellular proteins including erbin, ezrin, caspase-3, caspase-8, β-catenin, presenilin 1, and casein kinase II. E-cadherin is expressed in most epithelial cells and in erythroid cells. The E-cadherin antibody is often used as a neutralizing antibody to inhibit E-cadherin-mediated cell-cell interactions.
Subtype
Primary Antibodies
Target Antigen
E-Cadherin (CD324)
Alternative Names
Arc 1, Cadherin-1, CAM 120/80, CDHE, CDH1, E-Cad/CTF3, Epithelial cadherin, epithelial calcium-dependent adhesion protein, LCAM, Liver cell adhesion molecule, UVO, Uvomorulin
Reactive Species
Dog, Human, Mouse, Pig
Conjugation
Unconjugated
Host Species
Rat
Cell Type
Airway Cells
Application
Flow Cytometry, Functional Assay, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blotting
Area of Interest
Endothelial Cell Biology
Clone
DECMA-1
Gene ID
999/12550
Isotype
IgG1, kappa

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Anti-Mouse E-Cadherin (CD324) Antibody, Clone DECMA-1
Catalog #
60157, 60157.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse E-Cadherin (CD324) Antibody, Clone DECMA-1
Catalog #
60157, 60157.1
Lot #
All
Language
English

Educational Materials (1)

Brochure
PneumaCult™ Culture Media for Human Airway Epithelial Cells

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Data and Publications

Data

(A) Primary human airway epithelial cells were expanded in a submerged culture with PneumaCult™-Ex Medium (Catalog #05008). The cells were labeled with Anti-Mouse E-Cadherin (CD324) Antibody, Clone DECMA-1, followed by a donkey anti-mouse IgG antibody, Alexa Fluor® 488, and counterstained with DAPI. (B) Flow cytometry analysis of MDCK epithelial cells labeled with Anti-Mouse E-Cadherin (CD324) Antibody, Clone DECMA-1, followed by an anti-rat IgG1 antibody, PE (filled histogram) or Rat IgG1, kappa Isotype Control Antibody, Clone RTK2071 (Catalog #60075), followed by an anti-rat IgG1 antibody, PE (dotted line histogram).

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