Anti-Mouse E-Cadherin (CD324) Antibody, Clone DECMA-1

Rat monoclonal IgG1 antibody against human, mouse, dog E­-cadherin (CD324)

Anti-Mouse E-Cadherin (CD324) Antibody, Clone DECMA-1

Rat monoclonal IgG1 antibody against human, mouse, dog E­-cadherin (CD324)

From: 177 USD
Catalog #
60157_C
Rat monoclonal IgG1 antibody against human, mouse, dog E­-cadherin (CD324)

Overview

The DECMA-1 antibody recognizes E-cadherin, a calcium-dependent transmembrane glycoprotein involved in cell-cell adhesion, bacterial pathogenesis, and tumor invasion. The extracellular region of E-cadherin is composed of multiple cadherin repeats that contain calcium-binding motifs. The cytoplasmic domain of E-cadherin is reported to interact with a range of intracellular proteins including erbin, ezrin, caspase-3, caspase-8, β-catenin, presenilin 1, and casein kinase II. E-cadherin is expressed in most epithelial cells and in erythroid cells. The E-cadherin antibody is often used as a neutralizing antibody to inhibit E-cadherin-mediated cell-cell interactions.
Subtype
Primary Antibodies
Target Antigen
E-Cadherin (CD324)
Alternative Names
Arc 1, Cadherin-1, CAM 120/80, CDHE, CDH1, E-Cad/CTF3, Epithelial cadherin, epithelial calcium-dependent adhesion protein, LCAM, Liver cell adhesion molecule, UVO, Uvomorulin
Reactive Species
Dog, Human, Mouse, Pig
Conjugation
Unconjugated
Host Species
Rat
Cell Type
Airway Cells
Application
Flow Cytometry, Functional Assay, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blotting
Area of Interest
Endothelial Cell Biology
Clone
DECMA-1
Gene ID
999/12550
Isotype
IgG1, kappa

Data Figures

(A) Primary human airway epithelial cells were expanded in a submerged culture with PneumaCult™-Ex Medium (Catalog #05008). The cells were labeled with Anti-Mouse E-Cadherin (CD324) Antibody, Clone DECMA-1, followed by a donkey anti-mouse IgG antibody, Alexa Fluor® 488, and counterstained with DAPI. (B) Flow cytometry analysis of MDCK epithelial cells labeled with Anti-Mouse E-Cadherin (CD324) Antibody, Clone DECMA-1, followed by an anti-rat IgG1 antibody, PE (filled histogram) or Rat IgG1, kappa Isotype Control Antibody, Clone RTK2071 (Catalog #60075), followed by an anti-rat IgG1 antibody, PE (dotted line histogram).

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
60157, 60157.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
60157, 60157.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Resources and Publications

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