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The 214D4 antibody reacts with MUC1 (also known as CD227), a large cell surface glycoprotein expressed by most glandular and ductal epithelial cells as well as a variety of hematopoietic cells. A characteristic feature of the MUC1 (CD227) glycoprotein is a core protein domain composed of a variable number of tandem repeats and multiple oligosaccharide side chains. Because the extracellular portion of MUC1 can extend beyond most cell surface proteins, it is thought to play a role in cell-cell and cell-substrate adhesion. The protein is highly expressed by the majority of human adenocarcinomas and is associated with a poor prognosis. In the mammary gland, MUC1 is localized on the apical plasma membrane of luminal epithelial cells. The 214D4 antibody clone is particularly useful since it enriches for luminal-restricted but not bipotent epithelial progenitor cells from normal human mammary tissue.
Flow cytometry analysis of human MCF7 cells labeled with Anti-Human MUC1 (CD227) Antibody, Clone 214D4, followed by a rat anti-mouse IgG1 antibody, FITC (filled histogram) or a mouse IgG1, kappa isotype control antibody, followed by a rat anti-mouse IgG1 antibody, FITC (solid line histogram).
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Mouse monoclonal IgG1, kappa isotype control antibody
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Anti-Human MUC1 (CD227) Antibody, Clone 214D4
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
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