Anti-Human MUC1 (CD227) Antibody, Clone 214D4

Mouse monoclonal IgG1 antibody against human MUC1 (CD227)

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Anti-Human MUC1 (CD227) Antibody, Clone 214D4

Mouse monoclonal IgG1 antibody against human MUC1 (CD227), unconjugated

200 µg
Catalog #60137
768 USD

Overview

The 214D4 antibody reacts with MUC1 (also known as CD227), a large cell surface glycoprotein expressed by most glandular and ductal epithelial cells as well as a variety of hematopoietic cells. A characteristic feature of the MUC1 (CD227) glycoprotein is a core protein domain composed of a variable number of tandem repeats and multiple oligosaccharide side chains. Because the extracellular portion of MUC1 can extend beyond most cell surface proteins, it is thought to play a role in cell-cell and cell-substrate adhesion. The protein is highly expressed by the majority of human adenocarcinomas and is associated with a poor prognosis. In the mammary gland, MUC1 is localized on the apical plasma membrane of luminal epithelial cells. The 214D4 antibody clone is particularly useful since it enriches for luminal-restricted but not bipotent epithelial progenitor cells from normal human mammary tissue.
Subtype:
Primary Antibodies
Target Antigen:
MUC1 (CD227)
Alternative Names:
CD227, EMA, Episialin, Epithelial membrane antigen, HMFG antigen, MAM6, Mucin 1, PEM, Polymorphic epithelial mucin
Reactive Species:
Human
Conjugation:
Unconjugated
Host Species:
Mouse
Cell Type:
Mammary Cells
Application:
Cell Isolation; Immunohistochemistry
Area of Interest:
Stem Cell Biology; Epithelial Cell Biology
Clone:
214D4
Gene ID:
4582
Isotype:
IgG1

Scientific Resources

Educational Materials

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Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

Flow cytometry analysis of human MCF7 cells labeled with Anti-Human MUC1 (CD227) Antibody, Clone 214D4, followed by a rat anti-mouse IgG1 antibody, FITC (filled histogram) or a mouse IgG1, kappa isotype control antibody, followed by a rat anti-mouse IgG1 antibody, FITC (solid line histogram).

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.