Type 1 Diabetes Research
Type 1 diabetes (T1D) is characterized by the autoimmune-mediated destruction of pancreatic beta (β) cells, leading to the loss of insulin production and dysregulated glucose homeostasis. Researchers studying the disease use STEMCELL products to drive differentiation of human pluripotent stem cells (hPSCs) into pancreatic progenitors and insulin-producing cells, as well as to study autoimmune mechanisms underlying T1D disease progression. These tools have thus been used to support the modeling of pancreatic development and β-cell dysfunction in in vitro systems.
Explore STEMCELL products that have been cited in peer-reviewed publications advancing T1D research and helping to accelerate discovery and translational progress.
Featured Publications
- Johnson MB et al. (2024) Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency The Journal of Experimental Medicine 221(6):e20231704
- Wu X et al. (2024) CD39 delineates chimeric antigen receptor regulatory T cell subsets with distinct cytotoxic & regulatory functions against human islets Frontiers in Immunology 983.334722222222
- Wang X et al. (2025) Improving cellular fitness of human stem cell-derived islets under hypoxia Nature Communications 16(1):4787
- Wang K et al. (2025) Differentiation of patient-specific induced pluripotent stem cells derived from type 1 diabetes peripheral blood mononuclear cells into pancreatic β-like cells World Journal of Stem Cells 17(7):104607
- Zanfrini E et al. (2024) Generation and application of novel hES cell reporter lines for the differentiation and maturation of hPS cell-derived islet-like clusters Scientific Reports 14(1):19863
Products
Cell Culture Media and Supplements 4 (9)
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mTeSR™ Plus
cGMP, stabilized feeder-free maintenance medium for human ES and iPS cells -
ImmunoCult™ Human CD3/CD28/CD2 T Cell Activator
cGMP, human T cell activation and expansion reagent -
STEMdiff™ Pancreatic Progenitor Kit
Serum-free medium for the differentiation of human ES and iPS cells to pancreatic progenitor cells -
ImmunoCult™-XF T Cell Expansion Medium
Serum-free and xeno-free medium for the expansion of T cells
Primary and Cultured Cells 4 (2)
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Diseased Human Peripheral Blood Products, Diabetes, Type II
Diseased primary human cells, fresh or frozen -
Diseased Human Peripheral Blood Products, Diabetes, Type I
Diseased primary human cells, fresh or frozen
Tissue and Cell Culture Dissociation Reagents 4 (3)
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Gentle Collagenase/Hyaluronidase
10X Gentle collagenase/hyaluronidase in DMEM -
ACCUTASE™
Cell detachment solution -
ReLeSR™
cGMP, enzyme-free human pluripotent stem cell selection and passaging reagent
Small Molecules 4 (1)
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Y-27632 (Dihydrochloride)
RHO/ROCK pathway inhibitor; Inhibits ROCK1 and ROCK2
Cell Isolation Products 4 (4)
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EasySep™ Human CD4+CD127lowCD25+ Regulatory T Cell Isolation Kit
Immunomagnetic selection of human CD4+CD127lowCD25+ Tregs using particle release technology -
EasySep™ Human Monocyte Isolation Kit
Immunomagnetic negative isolation of untouched human CD14+CD16- monocytes -
EasySep™ Human CD4+ T Cell Isolation Kit
Immunomagnetic negative isolation of untouched human CD4+ T cells -
EasySep™ Human CD14 Positive Selection Kit II
Immunomagnetic positive selection of human CD14+ cells
