Mouse Recombinant IL-15

Interleukin 15

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Interleukin 15
From: 202 USD

Overview

Interleukin 15 (IL-15) is a four alpha-helix bundle cytokine with many similar properties to IL-2, with which it shares components of its receptor. IL-15 is produced by antigen-presenting cells, T cells, and B cells, as well as epithelial and stromal cells (Jabri & Abadie). The IL-15 receptor is a heterotrimeric receptor composed of IL-15Ra (the high-affinity receptor for IL-15), as well as IL-2/IL-15Rb (CD122) and common gamma chain (CD132). IL-15 binds to IL-15Ra and can then be presented in trans to IL-2/IL-15Rb and common gamma chain on other cells. Trans-presentation is thought to be the major mechanism by which IL-15-mediated responses occur in mice, although may not be necessary in humans (Castillo & Schluns). The cytoplasmic domains of IL-2/IL-15Rb and common gamma chain mediate signaling to activate JAK/STAT and PI3K pathways. IL-15 supports the survival and proliferation of CD8+ T cells, and promotes homeostasis of memory T cells. IL-15 also promotes the survival and differentiation of NK cells and regulates their cytolytic activity (Ma et al.).
Alternative Names:
IL-T, Interleukin-15
Cell Type:
Hematopoietic Stem and Progenitor Cells; Lymphocytes; NK Cells
Species:
Mouse
Area of Interest:
Immunology; Stem Cell Biology
Molecular Weight:
13.4 kDa
Purity:
≥ 95%

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(4)

Data and Publications

Data

(A) The biological activity of Mouse Recombinant IL-15 was tested by its ability to promote the proliferation of CTLL-2 cells. Cell proliferation was measured after 65 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the protein at which cell proliferation is at 50% of maximum. The EC50 in the example above is 4.1 ng/mL. (B) 1 μg of Mouse Recombinant IL-15 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant IL-15 has a predicted molecular mass of 13.4 kDa.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.