Troglitazone

NF-kB pathway inhibitor; Activates PPARγ
Catalog #
73892_C
NF-kB pathway inhibitor; Activates PPARγ
From: 71 USD

Overview

Troglitazone is a potent and selective activator of peroxisome proliferator-activated receptor-γ (PPARγ) with EC50 = 0.55 and 0.78 µM for human and mouse, respectively. Troglitazone does not inhibit PPARα or PPARδ at up to 10 µM (Willson et al.). Troglitazone causes cell cycle arrest at phase G1, inducing caspase-dependent apoptosis in both HeLa and hepatocellular carcinoma cell lines (Yoshizawa et al.; Chang et al.).

DIFFERENTIATION
· Stimulates adipogenesis in 3T3-L1 cells (Jeong & Yoon).
· Inhibits macrophage differentiation (Chen Y et al.).

METABOLISM
· Exerts potent glucose-lowering effects in insulin-resistant diabetic animals and in non-insulin-dependent (type II) human diabetic subjects (Lee & Olefsky).

CANCER RESEARCH
· Inhibits growth and induces apoptosis in non-small cell lung carcinoma, bladder cancer, cervical cancer, and prostate cancer cells (Chen H-M et al.; Santha et al.; Satoh et al.; Yan et al.).

· Promotes cytostatic effects in MDA-MB-231 and MCF-7 breast cancer cell lines (Berthe et al.)
Alternative Names
Resulin; Rezulin
Cell Type
Adipocytes, Cancer Cells and Cell Lines, Mammary Cells, Monocytes
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Differentiation, Expansion
Area of Interest
Cancer, Disease Modeling
CAS Number
97322-87-7
Chemical Formula
C₂₄H₂₇NSO
Molecular Weight
441.5 g/mol
Purity
≥ 98%
Pathway
NF-κB
Target
PPARγ

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Troglitazone
Catalog #
73892
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Troglitazone
Catalog #
73892
Lot #
All
Language
English

Educational Materials (3)

Brochure
Cytokines, Chemokines and Growth Factors
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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