Human Recombinant TGF-alpha

Transforming growth factor alpha

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Transforming growth factor alpha
From: 39 USD

Overview

Transforming growth factor-alpha (TGF-α) a member of the epidermal growth factor (EGF) family that is expressed in normal epithelial cells, monocytes, macrophages, brain cells, keratinocytes, and cancer cells. TGF-α binds EGF receptor (EGFR) and activates tyrosine kinase signaling. In epidermal and epithelial cells, this results in proliferation and differentiation. TGF-α is not structurally or genetically related to TGF-β, and the two ligands act through different signaling pathways. In vitro, TGF-α was shown to stimulate anchorage-independent growth (Singh & Coffey).
Alternative Names:
ETGF, Sarcoma growth factor, TGF, TGF-α, TGF-type I, Transforming growth factor-alpha
Cell Type:
Mammary Cells; Prostate Cells; Airway Cells; Epithelial Cells
Species:
Human
Area of Interest:
Epithelial Cell Biology
Molecular Weight:
5.6 kDa
Purity:
≥ 95%

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Data and Publications

Data

(A) The biological activity of Human Recombinant TGF-alpha was tested by its ability to promote the proliferation of BALB/c 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 0.2 ng/mL. (B) 2 μg of Human Recombinant TGF-alpha was resolved with SDS-PAGE under reducing (+) conditions and visualized by Coomassie Blue staining.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.