Human Recombinant GRO-alpha (CXCL1)

Growth-regulated oncogene alpha
Catalog #
78063_C
Growth-regulated oncogene alpha
From: 228 USD

Overview

GRO (growth-regulated oncogene)-alpha or CXCL1 is a member of the CXC family, which plays an integral role in recruitment and activation of neutrophils in response to tissue injury and microbial infection. GRO-alpha was initially identified by its growth stimulatory activity on malignant melanoma cells (Anisowicz et al.; Bechara et al.). GRO-alpha is closely related to GRO-beta (CXCL2), GRO-gamma (CXCL3), and interleukin 8 (CXCL8). Receptor-binding studies have demonstrated that GRO-alpha, -beta, and -gamma signal mainly through G protein-coupled receptor CXCR2 (Ahuja & Murphy). GRO-alpha is expressed in epithelial cells, monocytes, fibroblasts, and melanocytes, and is further induced during inflammatory, epithelialization, and angiogenic processes, such as during healing of human burn wounds (Zaja-Milatovic & Richmond). GRO-alpha, along with CXCL8, has been found to be critical for neutrophil mobilization and degranulation, as well as for vascular permeabilization and angiogenesis (Rudack et al.). GRO-alpha also stimulates mitogenesis in certain human melanoma cells (Unemori et al.).
Subtype
Cytokines
Alternative Names
GRO-1, Growth related oncogene alpha, Melanoma growth stimulating activity alpha, MGSA-a, MGSA-alpha, NAP-3, Neutrophil activating protein 3
Cell Type
Cancer Cells and Cell Lines, Endothelial Cells, Granulocytes and Subsets
Species
Human
Area of Interest
Angiogenic Cell Research, Cancer, Epithelial Cell Biology, Immunology
Molecular Weight
7.8 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant GRO-alpha (CXCL1)
Catalog #
78063.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant GRO-alpha (CXCL1)
Catalog #
78063.1
Lot #
All
Language
English

Educational Materials (3)

Brochure
Hematopoietic Stem and Progenitor Cells - Products for Your Research
Brochure
Cytokines, Chemokines and Growth Factors
Wallchart
Human Immune Cytokines

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant GRO-alpha (CXCL1) was tested by its ability to mobilize Ca2+ in CHO-K1/Gα15/hCXCR2 cells (human Gα15 and human CXCR2 stably expressed in CHO-K1 cells). Ca2+ mobilization was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which Ca2+ mobilization is at 50% of maximum. The EC50 in the example above is less than 0.1 μg/mL. (B) 2 μg of Human Recombinant GRO-alpha (CXCL1) was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant GRO-alpha (CXCL1) has a predicted molecular mass of 7.8 kDa.

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