Human Recombinant EGFR

Epidermal growth factor receptor

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Epidermal growth factor receptor
From: 201 USD

Overview

Epidermal growth factor receptor (EGFR) is a type I transmembrane protein and receptor tyrosine kinase. EGFR has been shown to bind to some members of the EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, epiregulin, heparin-binding EGF, and neuregulin-2α. EGFR ligand binding induces homodimerization, as well as heterodimerization of EGFR with ErbB2 or with ligand-activated ErbB3 or ErbB4 (Schlessinger). Dimerization results in kinase activation, phosphorylation, and cell signaling, mediated primarily through MEK/ERF and AKT pathways (Navlonic et al.). EGFR signaling has been shown to regulate cell proliferation, differentiation, motility, and apoptosis. Elevated levels of EGFR have been correlated with carcinogenesis (Maihle et al.). Protein contains a His-residue tag at the carboxyl end of the polypeptide chain.
Alternative Names:
Avian erythroblastic leukemia viral oncogene homolog, Epidermal growth factor receptor, Erb-b2 receptor tyrosine kinase 1, ERBB1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, v-erb-b
Cell Type:
Brain Tumor Stem Cells; Endoderm, PSC-Derived; Hematopoietic Stem and Progenitor Cells; Mesenchymal Stem and Progenitor Cells; Mesoderm, PSC-Derived; Neural Cells, PSC-Derived; Neural Stem and Progenitor Cells; Neurons; Pluripotent Stem Cells; Prostate Cells
Species:
Human
Area of Interest:
Epithelial Cell Biology; Neuroscience; Stem Cell Biology
Molecular Weight:
69.4 kDa
Purity:
≥ 95%

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(4)

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Data

(A) The biological activity of Human Recombinant EGFR was tested by its ability to promote the proliferation of BALB/c 3T3 cells in the presence of 25 pg/mL EGF. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.81 µg/mL. (B) 2 μg of Human Recombinant EGFR was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant EGFR has a predicted molecular mass of 69.4 kDa.

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