Rat Recombinant EGF

Epidermal growth factor
Catalog #
78107_C
Epidermal growth factor
From: 84 USD

Overview

Epidermal growth factor (EGF) is the founding member of the EGF family of proteins and is characterized by high-affinity binding to various EGF receptors (EGFRs) and the production of mitogenic responses (Carpenter & Cohen). EGF promotes EGFR dimerization, resulting in activation of downstream pathways including PI3K, ERK1/2, JAK/STAT, β-catenin, and calcium signaling. EGF is secreted by the gut-associated salivary and Brunner’s glands, is found in a variety of body fluids, and stimulates cell proliferation and differentiation in rodent and neonatal human intestine (Wright et al.). Central nervous system stem cells also proliferate in response to the EGF stimulus (Reynolds & Weiss).
Subtype
Cytokines, Growth Factors
Alternative Names
Beta-urogastrone, Epidermal growth factor, HOMG4, Pro-epidermal growth factor, Pro-epidermal growth factor precursor, URG, Urogastrone
Cell Type
Brain Tumor Stem Cells, Endoderm, PSC-Derived, Hematopoietic Stem and Progenitor Cells, Mesenchymal Stem and Progenitor Cells, Mesoderm, PSC-Derived, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Neurons, Pluripotent Stem Cells, Prostate Cells
Species
Rat
Area of Interest
Cancer, Epithelial Cell Biology, Neuroscience, Stem Cell Biology
Molecular Weight
6.3 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Rat Recombinant EGF
Catalog #
78107, 78107.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Rat Recombinant EGF
Catalog #
78107, 78107.1
Lot #
All
Language
English

Educational Materials (5)

Brochure
Cytokines, Chemokines and Growth Factors
Brochure
hPSC-Derived Neural Cell Research
Brochure
Hematopoietic Stem and Progenitor Cells - Products for Your Research
Wallchart
Directed Differentiation of Pluripotent Stem Cells
Wallchart
SnapShot: Growing Organoids from Stem Cells

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Rat Recombinant EGF was tested by its ability to promote the proliferation of BALB/c 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 0.08 ng/mL. (B) 2 μg of Rat Recombinant EGF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

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