Minocycline

Antibiotic with anti-inflammatory and neuroprotective properties
Minocycline (Hydrochloride Hydrate)

Antibiotic with anti-inflammatory and neuroprotective properties

100 mg
Catalog # 74114
207 USD
Minocycline (Hydrochloride Hydrate)

Antibiotic with anti-inflammatory and neuroprotective properties

25 mg
Catalog # 74112
52 USD

Overview

Minocycline is a semi-synthetic tetracycline and antibiotic broadly used to treat various bacterial infections. It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It has also been reported to chelate with Ca2+ and Mg2+ (Lambs et al.). Reported to be anti-inflammatory, immunomodulatory, and neuroprotective (Garrido-Mesa et al.), some of its mechanism of actions include inhibiting enzymatic activities of inducible nitric oxide synthase (Amin et al.), matrix metalloproteinases (Golub et al.), and phospholipase A2 (Pruzanski et al.), inhibiting activation of caspase-1 and caspase-3 (Chen et al.), inhibiting activity of poly(ADP-ribose) polymerase 1 (Alano et al.), and reduction of p38 MAPK phosphorylation (Corbacella et al.). This product is supplied as the hydrochloride salt of the molecule.


REPROGRAMMING
· Enables derivation of extended pluripotent stem cells from both humans and mice (Yang et al.).

IMMUNOLOGY
· Reduces the production of interleukin-8 elicited by activation of protease-activated receptor 2 in normal human epidermal keratinocytes, thus attenuating the proinflammatory reactions (Ishikawa et al.).

DISEASE MODELING
· Enhances survival of neural stem cells in rat model of Ischemia (Sakata et al.).
· Supports neuroprotective effects in animal models of Parkinson’s disease (Du et al.), Huntington’s disease (Chen et al.), amyotrophic lateral sclerosis (Zhu et al.), Alzheimer’s disease (Choi et al.), multiple sclerosis (Brundula et al.), and spinal cord injury (Festoff et al.; Garrido-Mesa et al.).
· Reduces bone and cartilage damage in rheumatoid arthritis via inhibition of collagenase and proteinase activity (Greenwald et al.; Arsenis et al.).
Alternative Names
Minomycin; NSC 141993
Cell Type
Keratinocytes, Macrophages, Pluripotent Stem Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Reprogramming
Area of Interest
Disease Modeling, Epithelial Cell Biology, Immunology, Neuroscience, Stem Cell Biology
Chemical Formula
C₂₃H₂₇N₃O₇ • HCl • XHO
Molecular Weight
493.9 g/mol
Purity
≥ 98%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Minocycline (Hydrochloride Hydrate)
Catalog #
74114, 74112
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Minocycline (Hydrochloride Hydrate)
Catalog #
74114, 74112
Lot #
All
Language
English

Educational Materials (3)

Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Mini Review
Small Molecules

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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