Phorbol 12-myristate 13-acetate

PKC pathway activator; Activates protein kinase C
Catalog #
74042_C
PKC pathway activator; Activates protein kinase C
From: 72 EUR

Overview

Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a reversible, highly potent activator of protein kinase C (PKC), including Group A and Group B isoforms (Blumberg). PMA activates PKC isoforms through the binding of the C1 domain (Hurley et al.). PMA can also activate certain mitogen-activated protein (MAP) kinase pathways through PKC (Adams & Parker).


DIFFERENTIATION
· Stimulates cardiac differentiation of mesenchymal stem cells (Seo et al.).

· Promotes hematopoietic differentiation (Clemens et al.).

IMMUNOLOGY

· Stimulates differentiation of IL-15-stimulated lamina propria CD4+ T cells into CXCR5+CD4+ cells when used together with ionomicin (Sarra et al.).

CANCER RESEARCH
· In combination with AS101, it shows anti-leukemic activity and stimulates human leukemia cell lines to differentiate into macrophage-like cells (Glesne & Huberman; Hayun et al.).
Alternative Names
12-O-Tetradecanoylphorbol-13-acetate; PMA; TPA
Cell Type
Cancer Cells and Cell Lines, Mesenchymal Stem and Progenitor Cells, Monocytes, T Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Differentiation
Area of Interest
Cancer, Immunology, Stem Cell Biology
CAS Number
16561-29-8
Chemical Formula
C₃₆H₅₆O
"
Molecular Weight
616.8 g/mol
Purity
≥ 98%
Pathway
PKC

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet 1
Product Name
Phorbol 12-myristate 13-acetate
Catalog #
74042, 74044
Lot #
BX37576 or higher
Language
English
Document Type
Product Information Sheet 2
Product Name
Phorbol 12-myristate 13-acetate
Catalog #
74042, 74044
Lot #
BX24678 or lower
Language
English
Document Type
Product Information Sheet 3
Product Name
Phorbol 12-myristate 13-acetate
Catalog #
74042, 74044
Lot #
BX24679 to BX37212
Language
English
Document Type
Safety Data Sheet
Product Name
Phorbol 12-myristate 13-acetate
Catalog #
74042, 74044
Lot #
All
Language
English

Educational Materials (6)

Brochure
Small Molecules for Cancer Research
Brochure
Cytokines, Chemokines and Growth Factors
Brochure
Small Molecules for Stem Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Wallchart
Human Immune Cytokines
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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