Human/Mouse Recombinant TGF-beta 3

Transforming growth factor beta 3
Catalog #
78131_C
Transforming growth factor beta 3
From: 168 EUR

Overview

Transforming growth factor (TGF) beta 3 is a member of the TGF-β superfamily and regulates diverse cellular phenotypes. TGF-beta 3 binds to serine-threonine kinase type I and II receptors and activates signal transduction through SMAD2/3 proteins, thus regulating a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, and metabolism (Massagué; McDowell et al.). TGF-beta 3 enhances glycosaminoglycan production by mesenchymal stromal cells, stimulates scar-free healing, and improves glucose tolerance and phenotypic changes in adipocyte morphology (Hall et al.; Holton et al.). TGF-beta 3 induces proliferation of posterofrontal suture-derived mesenchymal stromal cells, and stimulates expression of fibroblast growth factors 2 and 18 (James et al.).
Subtype
Cytokines, Growth Factors
Alternative Names
ARVD, FLJ16571, TGFB3, TGF-b3, Transforming growth factor beta-3
Cell Type
Mesenchymal Cells, PSC-Derived, Mesenchymal Stem and Progenitor Cells
Species
Human, Mouse
Area of Interest
Stem Cell Biology
Molecular Weight
12.9 kDa monomer; 25.7 kDa dimer
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human/Mouse Recombinant TGF-beta 3
Catalog #
78131, 78131.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human/Mouse Recombinant TGF-beta 3
Catalog #
78131, 78131.1
Lot #
All
Language
English

Educational Materials (4)

Brochure
Cytokines, Chemokines and Growth Factors
Brochure
Small Molecules for Stem Cell Research
Brochure
STEMdiff™ Mesoderm Induction Medium
Wallchart
The Identity and Properties of Mesenchymal Stem Cells

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human/Mouse Recombinant TGF-beta 3 was tested by its ability to inhibit proliferation of HT-2 cells in the presence of IL-4. Inhibition of cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation inhibition is at 50% of maximum. The EC50 in the example above is 0.0445 ng/mL. (B) 1 μg of Human/Mouse Recombinant TGF-beta 3 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

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