Human Recombinant FGF-6, ACF

Fibroblast growth factor 6, animal component-free

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Fibroblast growth factor 6, animal component-free
From: 166 USD

Overview

Fibroblast growth factor 6 (FGF-6) is a heparin-binding member of the FGF family, which are regulators of cell proliferation, differentiation, and function. FGF-6 binds and signals through the FGF receptors 1c, 2c, and 4 (Ornitz et al.). FGF-6 is a potent mitogen for fibroblasts, vascular endothelial cells, and prostate carcinoma cells (Asada et al.; Pizette et al.; Ropiquet et al.). FGF-6 is primarily expressed in epithelial and mesenchymal cell lineages. In development, FGF-6 is expressed in skeletal muscle, consistent with its role in muscle differentiation and regeneration (Floss et al.). FGF-6 has also been shown to promote chondrogenesis in embryonic somites in conjunction with transforming growth factor beta 2 (TGF-β2; Grass et al.). This product is animal component-free.
Alternative Names:
Fibroblast growth factor 6, HBGF-6, Heparin-binding growth factor 6, Heparin secretory-transforming protein 2, HST-2, HSTF-2
Cell Type:
Endothelial Cells; Fibroblasts; Mesenchymal Stem and Progenitor Cells; Prostate Cells
Species:
Human
Area of Interest:
Endothelial Cell Biology; Stem Cell Biology
Molecular Weight:
18.9 kDa
Purity:
≥ 95%

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Data and Publications

Data

(A) The biological activity of Human Recombinant FGF-6, ACF was tested by its ability to promote proliferation of NR6R-3T3 cells in the presence of 1 μg heparin. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is 0.00442 ng/mL. (B) 1 μg of Human Recombinant FGF-6, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-6, ACF has a predicted molecular mass of 18.9 kDa.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.