NU7441
NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)
Overview
NU7441 is an inhibitor of DNA-dependent protein kinase (DNA-PK), an enzyme involved in the non-homologous end joining (NHEJ) DNA repair pathway. It is highly selective for DNA-PK, with an IC₅₀ of 14 nM (Leahy et al.).
GENOME EDITING
·Reduces the frequency of NHEJ and increases the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Robert et al.).
CANCER RESEARCH
· Sensitizes human cancer cell lines to DNA double-strand-break-inducing therapies (chemo- or radio-therapy) by inhibiting DNA-PK activity and delaying the repair of double-strand breaks (Ciszewski et al.; Shaheen et al.; Yang et al.; Zhao et al.).
GENOME EDITING
·Reduces the frequency of NHEJ and increases the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Robert et al.).
CANCER RESEARCH
· Sensitizes human cancer cell lines to DNA double-strand-break-inducing therapies (chemo- or radio-therapy) by inhibiting DNA-PK activity and delaying the repair of double-strand breaks (Ciszewski et al.; Shaheen et al.; Yang et al.; Zhao et al.).
Alternative Names
KU57788
Cell Type
Cancer Cells and Cell Lines, Prostate Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Genome Editing
Area of Interest
Cancer
CAS Number
503468-95-9
Chemical Formula
C₂₅H₁₉NO₃S
Molecular Weight
413.5 g/mol
Purity
≥ 98%
Related Products
Related Products
Scientific Resources
Product Documentation
| Document Type | Product Name | Catalog # | Lot # | Language |
|---|---|---|---|---|
|
Document Type
Product Information Sheet
|
Product Name
NU7441
|
Catalog #
74082, 74084 |
Lot #
All |
Language
English |
|
Document Type
Safety Data Sheet
|
Product Name
NU7441
|
Catalog #
74082, 74084 |
Lot #
All |
Language
English |
Educational Materials (3)
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Mini Review
Small Molecules
Product Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for
Mammary Epithelial Cell Research
Workflow Stages for
Genome Editing
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
