BSI-201

Cysteine-containing protein modifier; Inhibits growth of triple-negative breast cancer cells
BSI-201

Cysteine-containing protein modifier; Inhibits growth of triple-negative breast cancer cells

50 mg
Catalog # 74122
359 USD

Overview

BSI-201, also known as iniparib, can interact with the zinc finger domain of poly(ADP-ribose) polymerase 1 (PARP1) in vitro, but fails to inhibit the enzyme (Patel et al.). The nitroso metabolite of BSI-201 is highly reactive and forms non-specific covalent interactions with many cysteine-containing proteins (Liu et al.). BSI-201 has demonstrated anti-proliferative effects in triple-negative breast cancer cells (Chuang et al.; Yin et al.), and early studies indicated that it may be useful in treating early-stage triple-negative and BRCA1/2 mutation-associated breast cancer (O’Shaughnessy et al. 2009); however, its efficacy was later found to be insignificant (O’Shaughnessy et al. 2014).


REPROGRAMMING
· When used in combination with other small molecules, enables derivation of extended pluripotent stem (EPS) cells from both humans and mice (Yang et al.).

CANCER RESEARCH
· Inhibits the growth of a subset of triple-negative breast cancer cells (Myc/MDA-231), in combination with cisplatin (Chuang et al.; Yin et al.).
Alternative Names
Iniparib; IND 71677
Cell Type
Cancer Cells and Cell Lines
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Reprogramming
Area of Interest
Cancer
CAS Number
160003-66-7
Chemical Formula
C₇H₅IN₂O₃
Molecular Weight
292.0 g/mol
Purity
≥ 98%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
BSI-201
Catalog #
74122
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
BSI-201
Catalog #
74122
Lot #
All
Language
English

Educational Materials (3)

Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Mini Review
Small Molecules

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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