In Vitro Circulatory System Tools for NAMs

Diseases of the circulatory system can impair blood cell production and regeneration, as well as compromise cardiac function. Human in vitro circulatory system models enable you to study these conditions at both phenotypic and mechanistic levels. By working within scalable, physiologically relevant systems, you can identify novel targets and uncover causal links between putative targets and disease-associated dysfunction.

In drug discovery, the circulatory system also plays a pivotal role in distributing therapeutic agents throughout the body and is a frequent site of off-target effects. From screening for cardiac liabilities to characterizing the impact of a putative therapy on hematopoiesis, human in vitro tissue models of the circulatory system are useful tools to deploy in new approach methodologies (NAMs) to understand tissue-specific toxicities. Human in vitro circulatory system models provide practical solutions for ranking and categorizing toxicity between compounds, but also to interrogate the toxicity-structure relationship in a highly physiologically relevant model system.

Beyond safety screening, you can leverage circulatory system models to support biomarker discovery and translational research. By enabling measurement of functional, cellular, and molecular endpoints, these systems facilitate identification and validation of predictive safety and efficacy biomarkers, strengthening the link between preclinical findings and clinical outcomes.

Explore in vitro circulatory system tools for your NAM development.